Function and synthesis of small nucleolar RNAs

D Tollervey, Tamás Kiss

Research output: Contribution to journalArticlepeer-review

Abstract

Eukaryotic cells contain an extraordinarily complex population of small nucleolar RNAs (snoRNAs). During its brief lifetime, each human pre-rRNA molecule will transiently associate with similar to 150 different snoRNA species, In the past year our understanding of snoRNAs has been clarified by the recognition that the snoRNA population can be divided into a small number of groups which are structurally and functionally distinct, The two largest groups of snoRNAs direct the site-specific modification of the pre-rRNA at positions of 2'-O-methylation and pseudouridine formation. Other groups of snoRNAs function in pre-rRNA cleavage and in the formation of the correct structure of the pre-rRNA.

Original languageEnglish
Pages (from-to)337-342
Number of pages6
JournalCurrent opinion in cell biology
Volume9
Issue number3
DOIs
Publication statusPublished - Jun 1997

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