Functional Amyloid and Other Protein Fibers in the Biofilm Matrix

Elliot Erskine, Cait E. MacPhee*, Nicola R. Stanley-Wall

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Biofilms are ubiquitous in the natural and man-made environment. They are defined as microbes that are encapsulated in an extracellular, self-produced, biofilm matrix. Growing evidence from the genetic and biochemical analysis of single species biofilms has linked the presence of fibrous proteins to a functional biofilm matrix. Some of these fibers have been described as functional amyloid or amyloid-like fibers. Here we provide an overview of the biophysical and biological data for a wide range of protein fibers found in the biofilm matrix of Gram-positive and Gram-negative bacteria.

Original languageEnglish
Pages (from-to)3642-3656
Number of pages15
JournalJournal of Molecular Biology
Issue number20
Early online date8 Aug 2018
Publication statusPublished - 12 Oct 2018

Keywords / Materials (for Non-textual outputs)

  • biofilm matrix
  • curli
  • functional amyloid fibers
  • PSM
  • TasA


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