Functional analysis of the rodent CK1tau mutation in the circadian clock of a marine unicellular alga

Gerben van Ooijen; Sarah F Martin; Martin E Barrios-Llerena; Matthew Hindle; Thierry Le Bihan; John S O'Neill; Andrew J Millar

doi:10.1186/1471-2121-14-46

Functional analysis of the rodent CK1tau mutation in the circadian clock of a marine unicellular alga

Gerben van Ooijen, Sarah F Martin, Martin E Barrios-Llerena, Matthew Hindle, Thierry Le Bihan, John S O'Neill, Andrew J Millar

Research output: Contribution to journal › Article › peer-review

Abstract

Casein Kinase 1 (CK1) is one of few proteins known to affect cellular timekeeping across metazoans, and the naturally occurring CK1tau mutation shortens circadian period in mammals. Functional conservation of a timekeeping function for CK1 in the green lineage was recently identified in the green marine unicell Ostreococcus tauri, in spite of the absence of CK1's transcriptional targets known from other species. The short-period phenotype of CK1tau mutant in mammals depends specifically on increased CK1 activity against PERIOD proteins. To understand how CK1 acts differently upon the algal clock, we analysed the cellular and proteomic effects of CK1tau overexpression in O. tauri.

Original language	English
Article number	46
Journal	BMC Cell Biology
Volume	14
Issue number	1
DOIs	https://doi.org/10.1186/1471-2121-14-46
Publication status	Published - 15 Oct 2013

Keywords

Ostreococcus tauri
Systems Biology
Circadian Clocks
Protein Kinases
Cell Signaling

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10.1186/1471-2121-14-46

Functional analysis of the rodent CK1tau
This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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Does an Ancient Circadian Clock control transcriptional rhythms using a non transcriptional oscillator
Millar, A. & Le Bihan, T.
BBSRC
1/10/12 → 31/01/16
Project: Research
SynthSys; formerly CSBE: Centre for Systems Biology at Edinburgh
Millar, A., Beggs, J., Ghazal, P., Goryanin, I., Hillston, J., Plotkin, G., Tollervey, D., Walton, A. & Robertson, K.
BBSRC
8/01/07 → 31/12/12
Project: Research

Cite this

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title = "Functional analysis of the rodent CK1tau mutation in the circadian clock of a marine unicellular alga",

abstract = "Casein Kinase 1 (CK1) is one of few proteins known to affect cellular timekeeping across metazoans, and the naturally occurring CK1tau mutation shortens circadian period in mammals. Functional conservation of a timekeeping function for CK1 in the green lineage was recently identified in the green marine unicell Ostreococcus tauri, in spite of the absence of CK1's transcriptional targets known from other species. The short-period phenotype of CK1tau mutant in mammals depends specifically on increased CK1 activity against PERIOD proteins. To understand how CK1 acts differently upon the algal clock, we analysed the cellular and proteomic effects of CK1tau overexpression in O. tauri.",

keywords = "Ostreococcus tauri, Systems Biology, Circadian Clocks, Protein Kinases, Cell Signaling ",

author = "{van Ooijen}, Gerben and Martin, {Sarah F} and Barrios-Llerena, {Martin E} and Matthew Hindle and {Le Bihan}, Thierry and O'Neill, {John S} and Millar, {Andrew J}",

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AU - van Ooijen, Gerben

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AU - Hindle, Matthew

AU - Le Bihan, Thierry

AU - O'Neill, John S

AU - Millar, Andrew J

PY - 2013/10/15

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AB - Casein Kinase 1 (CK1) is one of few proteins known to affect cellular timekeeping across metazoans, and the naturally occurring CK1tau mutation shortens circadian period in mammals. Functional conservation of a timekeeping function for CK1 in the green lineage was recently identified in the green marine unicell Ostreococcus tauri, in spite of the absence of CK1's transcriptional targets known from other species. The short-period phenotype of CK1tau mutant in mammals depends specifically on increased CK1 activity against PERIOD proteins. To understand how CK1 acts differently upon the algal clock, we analysed the cellular and proteomic effects of CK1tau overexpression in O. tauri.

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KW - Systems Biology

KW - Circadian Clocks

KW - Protein Kinases

KW - Cell Signaling

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DO - 10.1186/1471-2121-14-46

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JO - BMC Cell Biology

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SN - 1471-2121

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Functional analysis of the rodent CK1tau mutation in the circadian clock of a marine unicellular alga

Abstract

Keywords

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Projects

Does an Ancient Circadian Clock control transcriptional rhythms using a non transcriptional oscillator

SynthSys; formerly CSBE: Centre for Systems Biology at Edinburgh

Cite this