Projects per year
Casein Kinase 1 (CK1) is one of few proteins known to affect cellular timekeeping across metazoans, and the naturally occurring CK1tau mutation shortens circadian period in mammals. Functional conservation of a timekeeping function for CK1 in the green lineage was recently identified in the green marine unicell Ostreococcus tauri, in spite of the absence of CK1's transcriptional targets known from other species. The short-period phenotype of CK1tau mutant in mammals depends specifically on increased CK1 activity against PERIOD proteins. To understand how CK1 acts differently upon the algal clock, we analysed the cellular and proteomic effects of CK1tau overexpression in O. tauri.
|Journal||BMC Cell Biology|
|Publication status||Published - 15 Oct 2013|
- Ostreococcus tauri
- Systems Biology
- Circadian Clocks
- Protein Kinases
- Cell Signaling
FingerprintDive into the research topics of 'Functional analysis of the rodent CK1tau mutation in the circadian clock of a marine unicellular alga'. Together they form a unique fingerprint.
- 2 Finished
Does an Ancient Circadian Clock control transcriptional rhythms using a non transcriptional oscillator
Millar, A. & Le Bihan, T.
1/10/12 → 31/01/16
SynthSys; formerly CSBE: Centre for Systems Biology at Edinburgh
Millar, A., Beggs, J., Ghazal, P., Goryanin, I., Hillston, J., Plotkin, G., Tollervey, D., Walton, A. & Robertson, K.
8/01/07 → 31/12/12