Functional consequences of pre- and postsynaptic expression of 2 synaptic plasticity

Rui Ponte Costa, Beatriz E.P. Mizusaki, P. Jesper Sjöström, Mark Van Rossum

Research output: Contribution to journalArticlepeer-review

Abstract

Growing experimental evidence shows that both homeostatic and Hebbian synaptic plasticity can be expressed presynaptically as well as postsynaptically. In this review, we start by discussing this evidence and methods used to determine expression loci. Next, we discuss func-tional consequences of this diversity in pre- and postsynaptic expression of both homeostatic and Hebbian synaptic plasticity. In particular, we explore the functional consequences of a bio-logically tuned model of pre- and postsynaptically expressed spike-timing-dependent plasticity complemented with postsynaptic homeostatic control. The pre- and postsynaptic expression in this model predicts 1) more reliable receptive fields and sensory perception, 2) rapid recovery of forgotten information (memory savings) and 3) reduced response latencies, compared to a model with postsynaptic expression only. Finally we discuss open questions that will require a considerable research effort to better elucidate how the specific locus of expression of homeostatic and Hebbian plasticity alters synaptic and network computations.
Original languageEnglish
Pages (from-to)1-10
Number of pages10
JournalPhilosophical Transactions of the Royal Society B: Biological Sciences
Volume372
Issue number1715
DOIs
Publication statusPublished - 16 Jan 2017

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