Functional conservation of Pax6 regulatory elements in humans and mice demonstrated with a novel transgenic reporter mouse

David A Tyas; T Ian Simpson; Catherine B Carr; Dirk A Kleinjan; Veronica van Heyningen; John O Mason; David Price

doi:10.1186/1471-213X-6-21

Functional conservation of Pax6 regulatory elements in humans and mice demonstrated with a novel transgenic reporter mouse

David A Tyas, T Ian Simpson, Catherine B Carr, Dirk A Kleinjan, Veronica van Heyningen, John O Mason, David Price

Research output: Contribution to journal › Article › peer-review

Abstract

The Pax6 transcription factor is expressed during development in the eyes and in specific CNS regions, where it is essential for normal cell proliferation and differentiation. Mice lacking one or both copies of the Pax6 gene model closely humans with loss-of-function mutations in the PAX6 locus. The sequence of the Pax6/PAX6 protein is identical in mice and humans and previous studies have shown structural conservation of the gene's regulatory regions.

Original language	English
Article number	21
Number of pages	11
Journal	BMC Developmental Biology
Volume	6
DOIs	https://doi.org/10.1186/1471-213X-6-21
Publication status	Published - 2006

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title = "Functional conservation of Pax6 regulatory elements in humans and mice demonstrated with a novel transgenic reporter mouse",

abstract = "The Pax6 transcription factor is expressed during development in the eyes and in specific CNS regions, where it is essential for normal cell proliferation and differentiation. Mice lacking one or both copies of the Pax6 gene model closely humans with loss-of-function mutations in the PAX6 locus. The sequence of the Pax6/PAX6 protein is identical in mice and humans and previous studies have shown structural conservation of the gene's regulatory regions.",

author = "Tyas, {David A} and Simpson, {T Ian} and Carr, {Catherine B} and Kleinjan, {Dirk A} and {van Heyningen}, Veronica and Mason, {John O} and David Price",

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doi = "10.1186/1471-213X-6-21",

language = "English",

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journal = "BMC Developmental Biology",

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T1 - Functional conservation of Pax6 regulatory elements in humans and mice demonstrated with a novel transgenic reporter mouse

AU - Tyas, David A

AU - Simpson, T Ian

AU - Carr, Catherine B

AU - Kleinjan, Dirk A

AU - van Heyningen, Veronica

AU - Mason, John O

AU - Price, David

PY - 2006

Y1 - 2006

N2 - The Pax6 transcription factor is expressed during development in the eyes and in specific CNS regions, where it is essential for normal cell proliferation and differentiation. Mice lacking one or both copies of the Pax6 gene model closely humans with loss-of-function mutations in the PAX6 locus. The sequence of the Pax6/PAX6 protein is identical in mice and humans and previous studies have shown structural conservation of the gene's regulatory regions.

AB - The Pax6 transcription factor is expressed during development in the eyes and in specific CNS regions, where it is essential for normal cell proliferation and differentiation. Mice lacking one or both copies of the Pax6 gene model closely humans with loss-of-function mutations in the PAX6 locus. The sequence of the Pax6/PAX6 protein is identical in mice and humans and previous studies have shown structural conservation of the gene's regulatory regions.

U2 - 10.1186/1471-213X-6-21

DO - 10.1186/1471-213X-6-21

M3 - Article

C2 - 16674807

VL - 6

JO - BMC Developmental Biology

JF - BMC Developmental Biology

SN - 1471-213X

M1 - 21

ER -

Functional conservation of Pax6 regulatory elements in humans and mice demonstrated with a novel transgenic reporter mouse

Abstract

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