Functional conservation of Pax6 regulatory elements in humans and mice demonstrated with a novel transgenic reporter mouse

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

The Pax6 transcription factor is expressed during development in the eyes and in specific CNS regions, where it is essential for normal cell proliferation and differentiation. Mice lacking one or both copies of the Pax6 gene model closely humans with loss-of-function mutations in the PAX6 locus. The sequence of the Pax6/PAX6 protein is identical in mice and humans and previous studies have shown structural conservation of the gene's regulatory regions.
Original languageEnglish
Article number21
Number of pages11
JournalBMC Developmental Biology
Volume6
DOIs
Publication statusPublished - 2006

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