Functional gene group analysis indicates no role for heterotrimeric g proteins in cognitive ability

W David Hill; Christiaan de Leeuw; Gail Davies; David Cherry McLachlan Liewald; Anthony Payton; Leone C A Craig; Lawrence J Whalley; Mike Horan; William Ollier; John M Starr; Neil Pendleton; Danielle Posthuma; Timothy C Bates; Ian J Deary

doi:10.1371/journal.pone.0091690

Functional gene group analysis indicates no role for heterotrimeric g proteins in cognitive ability

W David Hill, Christiaan de Leeuw, Gail Davies, David Cherry McLachlan Liewald, Anthony Payton, Leone C A Craig, Lawrence J Whalley, Mike Horan, William Ollier, John M Starr, Neil Pendleton, Danielle Posthuma, Timothy C Bates, Ian J Deary

Research output: Contribution to journal › Article › peer-review

Abstract

Previous functional gene group analyses implicated common single nucleotide polymorphisms (SNPs) in heterotrimeric G protein coding genes as being associated with differences in human intelligence. Here, we sought to replicate this finding using five independent cohorts of older adults including current IQ and childhood IQ, and using both gene- and SNP-based analytic strategies. No significant associations were found between variation in heterotrimeric G protein genes and intelligence in any cohort at either of the two time points. These results indicate that, whereas G protein systems are important in cognition, common genetic variation in these genes is unlikely to be a substantial influence on human intelligence differences.

Original language	English
Article number	e91690
Journal	PLoS ONE
Volume	9
Issue number	3
DOIs	https://doi.org/10.1371/journal.pone.0091690
Publication status	Published - 13 Mar 2014

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10.1371/journal.pone.0091690

Functional Gene Group Analysis Indicates No Role for Heterotrimeric G Proteins in Cognitive Ability
Copyright: © 2014 Hill et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Final published version, 249 KBLicence: Creative Commons: Attribution (CC-BY)

http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0091690

Centre for Cognitive Ageing and Cognitive Epidemiology Phase 2.
Maclullich, A.
1/09/13 → 31/08/19
Project: Research
RA2661 Centre for Cognitive Ageing and Cognitive Epidemiology Phase 2. Main Budget.
Deary, I., Gale, C., Holmes, M., Logie, P., Maclullich, A., Porteous, D., Seckl, J., Starr, J., Wardlaw, J. & Okely, J.
1/09/13 → 31/08/19
Project: Research
Brain White mater imaging and cognitive ageing in the Lothian Birth Cohort of 1936:II
Deary, I., Bastin, M., Penke, L., Starr, J. & Wardlaw, J.
MRC
8/06/11 → 7/03/15
Project: Research

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Hill, W. D., de Leeuw, C., Davies, G., Liewald, D. C. M., Payton, A., Craig, L. C. A., Whalley, L. J., Horan, M., Ollier, W., Starr, J. M., Pendleton, N., Posthuma, D., Bates, T. C., & Deary, I. J. (2014). Functional gene group analysis indicates no role for heterotrimeric g proteins in cognitive ability. PLoS ONE, 9(3), Article e91690. https://doi.org/10.1371/journal.pone.0091690

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title = "Functional gene group analysis indicates no role for heterotrimeric g proteins in cognitive ability",

abstract = "Previous functional gene group analyses implicated common single nucleotide polymorphisms (SNPs) in heterotrimeric G protein coding genes as being associated with differences in human intelligence. Here, we sought to replicate this finding using five independent cohorts of older adults including current IQ and childhood IQ, and using both gene- and SNP-based analytic strategies. No significant associations were found between variation in heterotrimeric G protein genes and intelligence in any cohort at either of the two time points. These results indicate that, whereas G protein systems are important in cognition, common genetic variation in these genes is unlikely to be a substantial influence on human intelligence differences.",

author = "Hill, {W David} and {de Leeuw}, Christiaan and Gail Davies and Liewald, {David Cherry McLachlan} and Anthony Payton and Craig, {Leone C A} and Whalley, {Lawrence J} and Mike Horan and William Ollier and Starr, {John M} and Neil Pendleton and Danielle Posthuma and Bates, {Timothy C} and Deary, {Ian J}",

note = "Funding: This work was supported by the Engineering and Physical research council (EPSRC), the Biological Sciences Research Council (BBSRC), the Medical Research Council (MRC), the Wellcome Trust, the Economic and Social Research Council (ESRC), and Netherlands Organization of Scientific Research NWO 645-000-003. The work was undertaken in The University of Edinburgh Centre for Cognitive Ageing and Cognitive Epidemiology, part of the cross council Lifelong Health and Wellbeing Initiative (G0700704/84698). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.",

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doi = "10.1371/journal.pone.0091690",

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AU - Hill, W David

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AU - Payton, Anthony

AU - Craig, Leone C A

AU - Whalley, Lawrence J

AU - Horan, Mike

AU - Ollier, William

AU - Starr, John M

AU - Pendleton, Neil

AU - Posthuma, Danielle

AU - Bates, Timothy C

AU - Deary, Ian J

N1 - Funding: This work was supported by the Engineering and Physical research council (EPSRC), the Biological Sciences Research Council (BBSRC), the Medical Research Council (MRC), the Wellcome Trust, the Economic and Social Research Council (ESRC), and Netherlands Organization of Scientific Research NWO 645-000-003. The work was undertaken in The University of Edinburgh Centre for Cognitive Ageing and Cognitive Epidemiology, part of the cross council Lifelong Health and Wellbeing Initiative (G0700704/84698). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

PY - 2014/3/13

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N2 - Previous functional gene group analyses implicated common single nucleotide polymorphisms (SNPs) in heterotrimeric G protein coding genes as being associated with differences in human intelligence. Here, we sought to replicate this finding using five independent cohorts of older adults including current IQ and childhood IQ, and using both gene- and SNP-based analytic strategies. No significant associations were found between variation in heterotrimeric G protein genes and intelligence in any cohort at either of the two time points. These results indicate that, whereas G protein systems are important in cognition, common genetic variation in these genes is unlikely to be a substantial influence on human intelligence differences.

AB - Previous functional gene group analyses implicated common single nucleotide polymorphisms (SNPs) in heterotrimeric G protein coding genes as being associated with differences in human intelligence. Here, we sought to replicate this finding using five independent cohorts of older adults including current IQ and childhood IQ, and using both gene- and SNP-based analytic strategies. No significant associations were found between variation in heterotrimeric G protein genes and intelligence in any cohort at either of the two time points. These results indicate that, whereas G protein systems are important in cognition, common genetic variation in these genes is unlikely to be a substantial influence on human intelligence differences.

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DO - 10.1371/journal.pone.0091690

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Functional gene group analysis indicates no role for heterotrimeric g proteins in cognitive ability

Abstract

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Projects

Centre for Cognitive Ageing and Cognitive Epidemiology Phase 2.

RA2661 Centre for Cognitive Ageing and Cognitive Epidemiology Phase 2. Main Budget.

Brain White mater imaging and cognitive ageing in the Lothian Birth Cohort of 1936:II

Cite this