Functional imaging of the human brain using a modular, fibre-less, high-density diffuse optical tomography system

Danial Chitnis, Robert J Cooper, Laura Dempsey, Samuel Powell, Simone Quaggia, David Highton, Clare Elwell, Jeremy C Hebden, Nicholas L Everdell

Research output: Contribution to journalArticlepeer-review

Abstract

We present the first three-dimensional, functional images of the human brain to be obtained using a fibre-less, high-density diffuse optical tomography system. Our technology consists of independent, miniaturized, silicone-encapsulated DOT modules that can be placed directly on the scalp. Four of these modules were arranged to provide up to 128, dual-wavelength measurement channels over a scalp area of approximately 60 × 65 mm2. Using a series of motor-cortex stimulation experiments, we demonstrate that this system can obtain high-quality, continuous-wave measurements at source-detector separations ranging from 14 to 55 mm in adults, in the presence of hair. We identify robust haemodynamic response functions in 5 out of 5 subjects, and present diffuse optical tomography images that depict functional haemodynamic responses that are well-localized in all three dimensions at both the individual and group levels. This prototype modular system paves the way for a new generation of wearable, wireless, high-density optical neuroimaging technologies.

Original languageEnglish
Pages (from-to)4275-4288
Number of pages14
JournalBiomedical Optics Express
Volume7
Issue number10
Early online date27 Sep 2016
DOIs
Publication statusPublished - 1 Oct 2016

Keywords

  • Journal Article

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