Functional involvement of PHOSPHO1 in matrix vesicle-mediated skeletal mineralization

Scott Roberts, Sonoko Narisawa, Dympna Harmey, José Luis Millán, Colin Farquharson

Research output: Contribution to journalArticlepeer-review


PHOSPHO1 is a phosphatase highly expressed in bone. We studied its functional involvement in mineralization through the use of novel small molecule inhibitors. PHOSPHO1 expression was present within matrix vesicles, and inhibition of enzyme action caused a decrease in the ability of matrix vesicles to calcify.
Original languageEnglish
Pages (from-to)617-27
Number of pages11
JournalJournal of Bone and Mineral Research
Issue number4
Publication statusPublished - Apr 2007


  • 2-Pyridinylmethylsulfinylbenzimidazoles
  • Alkaline Phosphatase
  • Animals
  • Base Sequence
  • Bone Matrix
  • Calcification, Physiologic
  • Cells, Cultured
  • Chickens
  • DNA Primers
  • Enzyme Inhibitors
  • Growth Plate
  • Humans
  • Immunohistochemistry
  • Male
  • Mice
  • Mice, Knockout
  • Osteoblasts
  • Phosphoric Monoester Hydrolases
  • Polymerase Chain Reaction
  • Thiadiazoles
  • Thiazoles


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