Functional weakness: clues to mechanism from the nature of onset

Jon Stone*, Charles Warlow, Michael Sharpe

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Background Functional weakness describes weakness which is inconsistent and incongruent with disease. It is also referred to as motor conversion disorder (DSM-IV), dissociative motor disorder (ICD-10) and 'psychogenic' paralysis. Studies of aetiology have focused on risk factors such as childhood adversity and life events; information on the nature and circumstance of symptom onset may shed light on the mechanism of symptom formation.

Aim To describe the mode of onset, associated symptoms and circumstances at the onset of functional weakness.

Methods Retrospective interviews administered to 107 adults with functional weakness of <2 years' duration. Results The sample was 79% female, mean age 39 years and median duration of weakness 9 months. Three distinct modes of onset were discerned. These were: sudden (n=49, 46%), present on waking (or from general anaesthesia) (n=16, 13%) or gradual (n=42, 39%). In 'sudden onset' cases, panic (n=29, 59%), dissociative symptoms (n=19, 39%) and injury to the relevant limb (n=10, 20%) were commonly associated with onset. Other associated symptoms were non-epileptic attacks, migraine, fatigue and sleep paralysis. In six patients the weakness was noticed first by a health professional. In 16% of all patients, no potentially relevant factors could be discerned.

Conclusions The onset of functional weakness is commonly sudden. Examining symptoms and circumstances associated closely with the onset suggests hypotheses for the mechanism of onset of weakness in vulnerable individuals.

Original languageEnglish
Pages (from-to)67-69
Number of pages3
JournalJournal of Neurology, Neurosurgery & Psychiatry
Issue number1
Publication statusPublished - Jan 2012

Keywords / Materials (for Non-textual outputs)

  • Adult
  • Conversion Disorder
  • Dissociative Disorders
  • Fatigue
  • Female
  • Humans
  • Interview, Psychological
  • Male
  • Migraine Disorders
  • Muscle Weakness
  • Panic Disorder
  • Wounds and Injuries


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