Fundamental concepts in genetics the genetics of inbreeding depression

Deborah Charlesworth, John H. Willis

Research output: Contribution to journalLiterature reviewpeer-review

Abstract / Description of output

Inbreeding depression-the reduced survival and fertility of offspring of related individuals-occurs in wild animal and plant populations as well as in humans, indicating that genetic variation in fitness traits exists in natural populations. Inbreeding depression is important in the evolution of outcrossing mating systems and, because intercrossing inbred strains improves yield (heterosis), which is important in crop breeding, the genetic basis of these effects has been debated since the early twentieth century. Classical genetic studies and modern molecular evolutionary approaches now suggest that inbreeding depression and heterosis are predominantly caused by the presence of recessive deleterious mutations in populations.

Original languageEnglish
Pages (from-to)783-796
Number of pages14
JournalNature Reviews Genetics
Volume10
Issue number11
DOIs
Publication statusPublished - Nov 2009

Fingerprint

Dive into the research topics of 'Fundamental concepts in genetics the genetics of inbreeding depression'. Together they form a unique fingerprint.

Cite this