G-protein-coupled receptor expression, function, and signaling in macrophages

Jane Lattin, David A Zidar, Kate Schroder, Stuart Kellie, David A Hume, Matthew J Sweet

Research output: Contribution to journalArticlepeer-review

Abstract

G-protein-coupled receptors (GPCRs) are widely targeted in drug discovery. As macrophages are key cellular mediators of acute and chronic inflammation, we review here the role of GPCRs in regulating macrophage function, with a focus on contribution to disease pathology and potential therapeutic applications. Within this analysis, we highlight novel GPCRs with a macrophage-restricted expression profile, which provide avenues for further exploration. We also review an emerging literature, which documents novel roles for GPCR signaling components in GPCR-independent signaling in macrophages. In particular, we examine the crosstalk between GPCR and TLR signaling pathways and highlight GPCR signaling molecules which are likely to have uncharacterized functions in this cell lineage.
Original languageEnglish
Pages (from-to)16-32
Number of pages17
JournalJournal of Leukocyte Biology
Volume82
Issue number1
DOIs
Publication statusPublished - Jul 2007

Keywords

  • Animals
  • Humans
  • Macrophages
  • Receptor Cross-Talk
  • Receptors, G-Protein-Coupled
  • Signal Transduction
  • Toll-Like Receptors

Fingerprint

Dive into the research topics of 'G-protein-coupled receptor expression, function, and signaling in macrophages'. Together they form a unique fingerprint.

Cite this