Projects per year
Abstract
The medial septum (MS) is required for theta rhythmic oscillations and grid cell firing in the medial entorhinal cortex (MEC). While GABAergic, glutamatergic, and cholinergic neurons project from the MS to the MEC, their synaptic targets are unknown. To investigate whether MSneurons innervate specific layers and cell types in the MEC, we expressed channelrhodopsin-2 in mouse MSneurons and used patch-clamp recording in brain slices to determine the response to light activation of identified cells in the MEC. Following activation of MS axons, we observed fast monosynaptic GABAergic IPSPs in the majority (>60%) of fast-spiking (FS) and low-threshold-spiking (LTS) interneurons in all layers of the MEC, but in only 1.5% of nonstellate principal cells (NSPCs) and in no stellate cells. We also observed fast glutamatergic responses to MS activation in a minority (
Original language | English |
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Pages (from-to) | 16739-16743 |
Number of pages | 5 |
Journal | Journal of Neuroscience |
Volume | 34 |
Issue number | 50 |
DOIs | |
Publication status | Published - 10 Dec 2014 |
Keywords / Materials (for Non-textual outputs)
- gamma
- interneuron
- lamina organization
- medial entorhinal cortex
- medial septum
- theta
- GAMMA OSCILLATIONS
- THETA-RHYTHM
- LAYER-II
- SPATIAL PERIODICITY
- FIRING FIELDS
- GRID CELLS
- NEURONS
- RAT
- HIPPOCAMPUS
- AREA
Fingerprint
Dive into the research topics of 'GABAergic Projections from the Medial Septum Selectively Inhibit Interneurons in the Medial Entorhinal Cortex'. Together they form a unique fingerprint.Projects
- 4 Finished
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A systems approach to the cellular and molecular organization of neural circuits for representation of space
1/01/14 → 31/12/16
Project: Research
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An investigation of synaptic and molecular mechanisms for neural respresentation of space
1/10/12 → 31/12/17
Project: Research
Profiles
-
Matthew Nolan
- Deanery of Biomedical Sciences - Personal Chair of Neural Circuits and Computation
- Centre for Discovery Brain Sciences
- Edinburgh Neuroscience
Person: Academic: Research Active
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Gulsen Surmeli
- Deanery of Biomedical Sciences - Senior Lecturer
- Centre for Discovery Brain Sciences
- Edinburgh Neuroscience
Person: Academic: Research Active