GABAergic Projections from the Medial Septum Selectively Inhibit Interneurons in the Medial Entorhinal Cortex

Alfredo Gonzalez Sulser, Daniel Parthier, Antonio Candela, Christina McClure, Hugh Pastoll, Derek Garden, Gulsen Surmeli, Matthew F. Nolan*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

The medial septum (MS) is required for theta rhythmic oscillations and grid cell firing in the medial entorhinal cortex (MEC). While GABAergic, glutamatergic, and cholinergic neurons project from the MS to the MEC, their synaptic targets are unknown. To investigate whether MSneurons innervate specific layers and cell types in the MEC, we expressed channelrhodopsin-2 in mouse MSneurons and used patch-clamp recording in brain slices to determine the response to light activation of identified cells in the MEC. Following activation of MS axons, we observed fast monosynaptic GABAergic IPSPs in the majority (>60%) of fast-spiking (FS) and low-threshold-spiking (LTS) interneurons in all layers of the MEC, but in only 1.5% of nonstellate principal cells (NSPCs) and in no stellate cells. We also observed fast glutamatergic responses to MS activation in a minority (

Original languageEnglish
Pages (from-to)16739-16743
Number of pages5
JournalJournal of Neuroscience
Volume34
Issue number50
DOIs
Publication statusPublished - 10 Dec 2014

Keywords

  • gamma
  • interneuron
  • lamina organization
  • medial entorhinal cortex
  • medial septum
  • theta
  • GAMMA OSCILLATIONS
  • THETA-RHYTHM
  • LAYER-II
  • SPATIAL PERIODICITY
  • FIRING FIELDS
  • GRID CELLS
  • NEURONS
  • RAT
  • HIPPOCAMPUS
  • AREA

Fingerprint

Dive into the research topics of 'GABAergic Projections from the Medial Septum Selectively Inhibit Interneurons in the Medial Entorhinal Cortex'. Together they form a unique fingerprint.

Cite this