Gamma Interferon Fails To Induce Expression of Indoleamine 2,3-Dioxygenase and Does Not Control the Growth of Chlamydophila abortus in BeWo Trophoblast Cells

Gary Entrican, Sean Wattegedera, Michelle Chui, Lyn Oemar, Mara Rocchi, Colin McInnes

Research output: Contribution to journalArticlepeer-review

Abstract

The BeWo trophoblast cell line does not constitutively express the tryptophan degrading enzyme indolamine 2,3-dioxygenase (IDO), nor can IDO expression be induced by gamma interferon. This correlates with the inability of BeWo cells to control the growth of Chlamydophila abortus, in contrast to effects observed in HeLa cells treated with gamma interferon.
Original languageEnglish
Pages (from-to)2690-3
Number of pages4
JournalInfection and Immunity
Volume70
Issue number5
DOIs
Publication statusPublished - May 2002

Keywords

  • Abortion, Spontaneous
  • Chlamydophila
  • Chlamydophila psittaci
  • Enzyme Induction
  • Female
  • HeLa Cells
  • HUMANS
  • Indoleamine-Pyrrole 2,3,-Dioxygenase
  • Interferon-gamma
  • PREGNANCY
  • Trophoblasts
  • Tryptophan
  • Tumor Cells, Cultured

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