Gas-Phase Synthesis of Pyrazolo[3,4-b]pyridin-4-ones

Martha Mackay, Andrew Nortcliffe, Hamish McNab, Alison Hulme

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Flash vacuum pyrolysis (FVP) at 500–600 °C of 1-substituted pyrazolylaminomethylene derivatives of Meldrum’s acid provides 1-substituted pyrazolo[3,4-b]pyridin-4-ones in high yields. If the 1-substituent is a tert-butyl group, FVP at 750–850 °C causes elimination of 2-methyl-1-propene to give the parent pyrazolo[3,4-b]pyridin-4-one.
Original languageEnglish
Pages (from-to)242-248
Number of pages7
JournalSynthesis: Journal of Synthetic Organic Chemistry
Early online date2 Oct 2014
Publication statusPublished - 2014

Keywords / Materials (for Non-textual outputs)

  • gas-phase reactions
  • pericyclic reactions
  • heterocycles
  • Meldrum’s acid
  • medicinal chemistry


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