Projects per year
Abstract
Here we conducted a large-scale genetic association analysis of educational attainment in a sample of approximately 1.1 million individuals and identify 1,271 independent genome-wide-significant SNPs. For the SNPs taken together, we found evidence of heterogeneous effects across environments. The SNPs implicate genes involved in brain-development processes and neuron-to-neuron communication. In a separate analysis of the X chromosome, we identify 10 independent genome-wide-significant SNPs and estimate a SNP heritability of around 0.3% in both men and women, consistent with partial dosage compensation. A joint (multi-phenotype) analysis of educational attainment and three related cognitive phenotypes generates polygenic scores that explain 11-13% of the variance in educational attainment and 7-10% of the variance in cognitive performance. This prediction accuracy substantially increases the utility of polygenic scores as tools in research.
Original language | English |
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Pages (from-to) | 1112-+ |
Number of pages | 16 |
Journal | Nature Genetics |
Volume | 50 |
Issue number | 8 |
Early online date | 23 Jul 2018 |
DOIs | |
Publication status | Published - Aug 2018 |
Keywords / Materials (for Non-textual outputs)
- MAPPING CAUSAL VARIANTS
- HUMAN TRAITS
- HUMAN BRAIN
- STATISTICS
- HERITABILITY
- METAANALYSIS
- INTELLIGENCE
- LOCI
- GWAS
- POPULATIONS
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Dive into the research topics of 'Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals'. Together they form a unique fingerprint.Projects
- 3 Finished
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Stratifying Resilience and Depression Longitudinally
McIntosh, A. (Principal Investigator), Deary, I. (Co-investigator), Evans, K. (Co-investigator), Haley, C. (Co-investigator) & Porteous, D. (Co-investigator)
1/01/15 → 30/06/21
Project: Research
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Generation Scotland
Porteous, D. (Principal Investigator)
UK central government bodies/local authorities, health and hospital authorities
1/04/11 → 31/03/14
Project: Research
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Genetic Health 21st Century
Porteous, D. (Principal Investigator), Laurie, G. (Co-investigator) & Tait, J. (Co-investigator)
UK central government bodies/local authorities, health and hospital authorities
1/10/03 → 31/08/07
Project: Research