Gene expression heterogeneities in embryonic stem cell populations: origin and function

Alfonso Martinez Arias, Joshua M Brickman

Research output: Contribution to journalArticlepeer-review

Abstract

Stem and progenitor cells are populations of cells that retain the capacity to populate specific lineages and to transit this capacity through cell division. However, attempts to define markers for stem cells have met with limited success. Here we consider whether this limited success reflects an intrinsic requirement for heterogeneity with stem cell populations. We focus on Embryonic Stem (ES) cells, in vitro derived cell lines from the early embryo that are considered both pluripotent (able to generate all the lineages of the future embryo) and indefinitely self renewing. We examine the relevance of recently reported heterogeneities in ES cells and whether these heterogeneities themselves are inherent requirements of functional potency and self renewal.
Original languageEnglish
Pages (from-to)650-656
Number of pages7
JournalCurrent opinion in cell biology
Volume23
Issue number6
Early online date5 Oct 2011
DOIs
Publication statusPublished - 31 Dec 2011

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