Gene expression patterns in larval Schistosoma mansoni associated with infection of the mammalian host

Sophia J Parker-Manuel, Alasdair C Ivens, Gary P Dillon, R Alan Wilson

Research output: Contribution to journalArticlepeer-review

Abstract

The infective schistosome cercaria develops within the intramolluscan daughter sporocyst from an undifferentiated germ ball, during which synthesis of proteins essential for infection occurs. When the aquatic cercaria locates the mammalian host it rapidly penetrates into the epidermis using glandular secretions. It then undergoes metamorphosis into the schistosomulum, including replacement of its tegument surface membranes, a process taking several days before it exits the skin. Patterns of gene expression underlying this transition have been characterised.
Original languageEnglish
Article numbere1274
JournalPLoS Neglected Tropical Diseases
Volume5
Issue number8
DOIs
Publication statusPublished - Aug 2011

Keywords

  • Schistosoma mansoni
  • Gene Expression Profiling
  • Animals
  • Schistosomiasis mansoni
  • Larva
  • Microarray Analysis
  • Mice
  • Biomphalaria
  • Gene Expression Regulation, Developmental

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