Generation of bivalent chromatin domains during cell fate decisions

Marco De Gobbi; David Garrick; Magnus Lynch; Douglas Vernimmen; Jim R Hughes; Nicolas Goardon; Sidinh Luc; Karen M Lower; Jacqueline A Sloane-Stanley; Cristina Pina; Shamit Soneji; Raffaele Renella; Tariq Enver; Stephen Taylor; Sten Eirik W Jacobsen; Paresh Vyas; Richard J Gibbons; Douglas R Higgs

doi:10.1186/1756-8935-4-9

Generation of bivalent chromatin domains during cell fate decisions

Marco De Gobbi, David Garrick, Magnus Lynch, Douglas Vernimmen, Jim R Hughes, Nicolas Goardon, Sidinh Luc, Karen M Lower, Jacqueline A Sloane-Stanley, Cristina Pina, Shamit Soneji, Raffaele Renella, Tariq Enver, Stephen Taylor, Sten Eirik W Jacobsen, Paresh Vyas, Richard J Gibbons, Douglas R Higgs

Royal (Dick) School of Veterinary Studies

Research output: Contribution to journal › Article › peer-review

Abstract

In self-renewing, pluripotent cells, bivalent chromatin modification is thought to silence (H3K27me3) lineage control genes while 'poising' (H3K4me3) them for subsequent activation during differentiation, implying an important role for epigenetic modification in directing cell fate decisions. However, rather than representing an equivalently balanced epigenetic mark, the patterns and levels of histone modifications at bivalent genes can vary widely and the criteria for identifying this chromatin signature are poorly defined.

Original language	English
Pages (from-to)	1-12
Number of pages	12
Journal	Epigenetics and Chromatin
Volume	4
Issue number	9
DOIs	https://doi.org/10.1186/1756-8935-4-9
Publication status	Published - 2011

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De Gobbi, M., Garrick, D., Lynch, M., Vernimmen, D., Hughes, J. R., Goardon, N., Luc, S., Lower, K. M., Sloane-Stanley, J. A., Pina, C., Soneji, S., Renella, R., Enver, T., Taylor, S., Jacobsen, S. E. W., Vyas, P., Gibbons, R. J., & Higgs, D. R. (2011). Generation of bivalent chromatin domains during cell fate decisions. Epigenetics and Chromatin, 4(9), 1-12. https://doi.org/10.1186/1756-8935-4-9

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abstract = "In self-renewing, pluripotent cells, bivalent chromatin modification is thought to silence (H3K27me3) lineage control genes while 'poising' (H3K4me3) them for subsequent activation during differentiation, implying an important role for epigenetic modification in directing cell fate decisions. However, rather than representing an equivalently balanced epigenetic mark, the patterns and levels of histone modifications at bivalent genes can vary widely and the criteria for identifying this chromatin signature are poorly defined.",

author = "{De Gobbi}, Marco and David Garrick and Magnus Lynch and Douglas Vernimmen and Hughes, {Jim R} and Nicolas Goardon and Sidinh Luc and Lower, {Karen M} and Sloane-Stanley, {Jacqueline A} and Cristina Pina and Shamit Soneji and Raffaele Renella and Tariq Enver and Stephen Taylor and Jacobsen, {Sten Eirik W} and Paresh Vyas and Gibbons, {Richard J} and Higgs, {Douglas R}",

year = "2011",

doi = "10.1186/1756-8935-4-9",

language = "English",

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De Gobbi, M, Garrick, D, Lynch, M, Vernimmen, D, Hughes, JR, Goardon, N, Luc, S, Lower, KM, Sloane-Stanley, JA, Pina, C, Soneji, S, Renella, R, Enver, T, Taylor, S, Jacobsen, SEW, Vyas, P, Gibbons, RJ & Higgs, DR 2011, 'Generation of bivalent chromatin domains during cell fate decisions', Epigenetics and Chromatin, vol. 4, no. 9, pp. 1-12. https://doi.org/10.1186/1756-8935-4-9

TY - JOUR

T1 - Generation of bivalent chromatin domains during cell fate decisions

AU - De Gobbi, Marco

AU - Garrick, David

AU - Lynch, Magnus

AU - Vernimmen, Douglas

AU - Hughes, Jim R

AU - Goardon, Nicolas

AU - Luc, Sidinh

AU - Lower, Karen M

AU - Sloane-Stanley, Jacqueline A

AU - Pina, Cristina

AU - Soneji, Shamit

AU - Renella, Raffaele

AU - Enver, Tariq

AU - Taylor, Stephen

AU - Jacobsen, Sten Eirik W

AU - Vyas, Paresh

AU - Gibbons, Richard J

AU - Higgs, Douglas R

PY - 2011

Y1 - 2011

N2 - In self-renewing, pluripotent cells, bivalent chromatin modification is thought to silence (H3K27me3) lineage control genes while 'poising' (H3K4me3) them for subsequent activation during differentiation, implying an important role for epigenetic modification in directing cell fate decisions. However, rather than representing an equivalently balanced epigenetic mark, the patterns and levels of histone modifications at bivalent genes can vary widely and the criteria for identifying this chromatin signature are poorly defined.

AB - In self-renewing, pluripotent cells, bivalent chromatin modification is thought to silence (H3K27me3) lineage control genes while 'poising' (H3K4me3) them for subsequent activation during differentiation, implying an important role for epigenetic modification in directing cell fate decisions. However, rather than representing an equivalently balanced epigenetic mark, the patterns and levels of histone modifications at bivalent genes can vary widely and the criteria for identifying this chromatin signature are poorly defined.

U2 - 10.1186/1756-8935-4-9

DO - 10.1186/1756-8935-4-9

M3 - Article

C2 - 21645363

SN - 1756-8935

VL - 4

SP - 1

EP - 12

JO - Epigenetics and Chromatin

JF - Epigenetics and Chromatin

IS - 9

ER -

Generation of bivalent chromatin domains during cell fate decisions

Abstract

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