Generation of bivalent chromatin domains during cell fate decisions

Marco De Gobbi, David Garrick, Magnus Lynch, Douglas Vernimmen, Jim R Hughes, Nicolas Goardon, Sidinh Luc, Karen M Lower, Jacqueline A Sloane-Stanley, Cristina Pina, Shamit Soneji, Raffaele Renella, Tariq Enver, Stephen Taylor, Sten Eirik W Jacobsen, Paresh Vyas, Richard J Gibbons, Douglas R Higgs

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

In self-renewing, pluripotent cells, bivalent chromatin modification is thought to silence (H3K27me3) lineage control genes while 'poising' (H3K4me3) them for subsequent activation during differentiation, implying an important role for epigenetic modification in directing cell fate decisions. However, rather than representing an equivalently balanced epigenetic mark, the patterns and levels of histone modifications at bivalent genes can vary widely and the criteria for identifying this chromatin signature are poorly defined.
Original languageEnglish
Pages (from-to)1-12
Number of pages12
JournalEpigenetics and Chromatin
Issue number9
Publication statusPublished - 2011


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