Genes predict village of origin in rural Europe

Colm O'Dushlaine, Ruth McQuillan, Michael E. Weale, Daniel J. M. Crouch, Asa Johansson, Yurii Aulchenko, Christopher S. Franklin, Ozren Polasek, Christian Fuchsberger, Aiden Corvin, Andrew A. Hicks, Veronique Vitart, Caroline Hayward, Sarah H. Wild, Thomas Meitinger, Cornelia M. van Duijn, Ulf Gyllensten, Alan Wright, Harry Campbell, Peter P. PramstallerIgor Rudan, James F. Wilson

Research output: Contribution to journalArticlepeer-review

Abstract

The genetic structure of human populations is important in population genetics, forensics and medicine. Using genome-wide scans and individuals with all four grandparents born in the same settlement, we here demonstrate remarkable geographical structure across 8-30 km in three different parts of rural Europe. After excluding close kin and inbreeding, village of origin could still be predicted correctly on the basis of genetic data for 89-100% of individuals. European Journal of Human Genetics (2010) 18, 1269-1270; doi: 10.1038/ejhg.2010.92; published online 23 June 2010

Original languageEnglish
Pages (from-to)1269-1270
Number of pages2
JournalEuropean Journal of Human Genetics
Volume18
Issue number11
DOIs
Publication statusPublished - Nov 2010

Keywords

  • population structure
  • principal components
  • genome-wide genotyping

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