Genetic analysis of over one million people identifies 535 new loci associated with blood pressure traits

Evangelos Evangelou, Helen R. Warren, David Mosen-Ansorena, Borbala Mifsud, Raha Pazoki, He Gao, Georgios Ntritsos, Niki Dimou, Claudia Cabrera-Cardenas, Ibrahim Karaman, Fu Liang Ng, Marina Evangelou, Katarzyna Witkowska, Evan Tzanis, Jacklyn N Hellwege, Ayush Giri, Digna R Velez Edwards, Yan V Sun, Kelly Cho, J Michael GazianoPeter W F Wilson, Philip S Tsao, Csaba P Kovesdy, Tonu Esko, Reedik Mägi, Lili Milani, Peter Almgren, Thibaud Boutin, Stephanie Debette, Jun Ding, Franco Giulianini, Elizabeth G Holliday, Anne U. Jackson, Ruifang Li-Gao, Wei-Yu Lin, Jian'an Luan, Massimo Mangino, Christopher Oldmeadow, Bram Peter Prins, Yong Qian, Muralidharan Sargurupremraj, Nabi Shah, Praveen Surendran, Sebastien Theriault, Niek Verweij, Sara M. Willems, Jing Hua Zhao, Philippe Amouyel, John M C Connell, Renee de Mutsert, Alex S. F. Doney, Martin Farrall, Cristina Menni, Andrew Morris, Raymond Noordam, Guillaume Paré, Neil R Poulter, Denis C. Shields, Alice V. Stanton, Simon Thom, Gonçalo R Abecasis, Najaf Amin, Dan E. Arking, Kristin L. Ayers, Caterina M Barbieri, Chiara Batini, Joshua C. Bis, Tineka Blake, Murielle Bochud, Michael Boehnke, Eric Boerwinkle, Dorret I. Boomsma, Erwin P. Bottinger, Peter S Braund, Marco Brumat, Archibald Campbell, Harry Campbell, Aravinda Chakravarti, John C. Chambers, Ganesh Chauhan, Marina Ciullo, Massimiliano Cocca, Francis S. Collins, Heather J. Cordell, Gail Davies, Martin H de Borst, Eco J. C. Geus, Ian Deary, Joris Deelen, Fabiola M. Del Greco, Yusuf Demirkale, Marcus Dörr, Georg B. Ehret, Roberto Elosua, Stefan Enroth, A Mesut Erzurumluoglu, Teresa Ferreira, Mattias Frånberg, Oscar H. Franco, Ilaria Gandin, Paolo Gasparini, Vilmantas Giedraitis, Christian Gieger, Giorgia Girotto, Anuj Goel, Alan J. Gow, Vilmundur Gudnason, Xiuqing Guo, Ulf Gyllensten, Anders Hamsten, Tamara B. Harris, Sarah Harris, Catharina A. Hartman, Aki S. Havulinna, Andrew A. Hicks, Edith Hofer, Albert Hofman, Jouke-Jan Hottenga, Jennifer E. Huffman, Shih-Jen Hwang, Erik Ingelsson, Alan L James, Rick Jansen, Marjo-Riitta Jarvelin, Roby Joehanes, Åsa Johansson, Andrew D Johnson, Peter Joshi, Pekka Jousilahti, J. Wouter Jukema, Antti Jula, Mika Kähönen, Sekar Kathiresan, Bernard D. Keavney, Kay Tee Khaw, Paul Knekt, Joanne Knight, Ivana Kolcic, Jaspal S. Kooner, Seppo Koskinen, Kati Kristiansson, Zoltan Kutalik, Maris Laan, Marty Larson, Lenore J. Launer, Benjamin Lehne, Terho Lehtimäki, David Liewald, Li Lin, Lars Lind, Cecilia M Lindgren, Yongmei Liu, Ruth Jf Loos, Lorna Lopez, Yingchang Lu, Leo-Pekka Lyytikäinen, Anubha Mahajan, Chrysovalanto Mamasoula, Jaume Marrugat, Jonathan Marten, Yuri Milaneschi, Anna Morgan, Andrew P. Morris, Alanna C. Morrison, Peter J. Munson, Mike A. Nalls, Priyanka Nandakumar, Christopher P. Nelson, Teemu Niiranen, Ilja M. Nolte, Teresa Nutile, Albertine J Oldehinkel, Ben A. Oostra, Paul F. O'Reilly, Elin Org, Sandosh Padmanabhan, Walter Palmas, Aarno Palotie, Alison Pattie, B W J H Penninx, Markus Perola, Annette Peters, Ozren Polasek, Peter P. Pramstaller, Quang Tri Nguyen, Olli T. Raitakari, Meixia Ren, Rainer Rettig, Kenneth M. Rice, Paul M. Ridker, Janina S. Ried, Harriette Riese, Samuli Ripatti, Antonietta Robino, Lynda M. Rose, Jerome I. Rotter, Igor Rudan, Daniela Ruggiero, Yasaman Saba, Cinzia F Sala, Veikko Salomaa, Nilesh J Samani, Antti-Pekka Sarin, Reinhold Schmidt, Helena Schmidt, Nick R G Shrine, David S. Siscovick, Albert Vernon Smith, Harold Snieder, Siim Sõber, Rossella Sorice, John Starr, David J Stott, David P Strachan, Rona J. Strawbridge, Johan Sundstrom, Morris A. Swertz, Kent D. Taylor, Alexander Teumer, Martin D Tobin, Maciej Tomaszewski, Daniela Toniolo, Michela Traglia, Stella Trompet, Jaakko Tuomilehto, Christophe Tzourio, André G Uitterlinden, Ahmad Vaez, Peter J van der Most, Cornelia M van Duijn, Anne-Claire Vergnaud, Germaine C. Verwoert, Veronique Vitart, Uwe Völker, Peter Vollenweider, Dragana Vuckovic, Hugh Watkins, Sarah Wild, Gonneke Willemsen, James Wilson, Alan F. Wrightl, Jie Yao, Tatijana Zemunik, Weihua Zhang, John Attia, Adam S Butterworth, Daniel I. Chasman, David Conen, Francesco Cucca, John Danesh, Caroline Hayward, Joanna MM Howson, Markku Laakso, Edward G. Lakatta, Claudia Langenberg, Olle Melander, Dennis O Mook-Kanamori, Colin N A Palmer, Lorenz Risch, Robert A. Scott, Rodney J Scott, Peter Sever, Tim D Spector, Pim van der Harst, Nicholas J Wareham, Eleftheria Zeggini, Daniel Levy, Patricia B Munroe, Christopher Newton-Cheh, Morris J Brown, Andres Metspalu, Adriana M Hung, Christopher J. O'Donnell, Todd L Edwards, Bruce M. Psaty, Ioanna Tzoulaki, Michael R Barnes, Louise V Wain, Paul Elliott, Mark J Caulfield

Research output: Contribution to journalArticlepeer-review

Abstract

High blood pressure is a highly heritable and modifiable risk factor for cardiovascular disease. We report the largest genetic association study of blood pressure traits (systolic, diastolic, pulse pressure) to date in over one million people of European ancestry. We identify 535 novel blood pressure loci that not only offer new biological insights into blood pressure regulation but also reveal shared genetic architecture between blood pressure and lifestyle exposures. Our findings identify new biological pathways for blood pressure regulation with potential for improved cardiovascular disease prevention in the future.
Original languageEnglish
Pages (from-to)1412–1425
JournalNature Genetics
Volume50
DOIs
Publication statusPublished - 17 Sep 2018

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