Genetic ancestry is associated with colorectal adenomas and adenocarcinomas in Latino populations

Gustavo Hernandez-Suarez, Maria Carolina Sanabria, Marta Serrano, Oscar F Herran, Jesus Perez, Jose L Plata, Jovanny Zabaleta, Albert Tenesa

Research output: Contribution to journalArticlepeer-review


Colorectal cancer rates in Latin American countries are less than half of those observed in the United States. Latin Americans are the resultant of generations of an admixture of Native American, European, and African individuals. The potential role of genetic admixture in colorectal carcinogenesis has not been examined. We evaluate the association of genetic ancestry with colorectal neoplasms in 190 adenocarcinomas, 113 sporadic adenomas and 243 age- and sex-matched controls enrolled in a multicentric case-control study in Colombia. Individual ancestral genetic fractions were estimated using the STRUCTURE software, based on allele frequencies and assuming three distinct population origins. We used the Illumina Cancer Panel to genotype 1,421 sparse single-nucleotide polymorphisms (SNPs), and Northern and Western European ancestry, LWJ and Han Chinese in Beijing, China populations from the HapMap project as references. A total of 678 autosomal SNPs overlapped with the HapMap data set SNPs and were used for ancestry estimations. African mean ancestry fraction was higher in adenomas (0.13, 95% confidence interval (95% CI)=0.11-0.15) and cancer cases (0.14, 95% CI=0.12-0.16) compared with controls (0.11, 95% CI=0.10-0.12). Conditional logistic regression analysis, controlling for known risk factors, showed a positive association of African ancestry per 10% increase with both colorectal adenoma (odds ratio (OR)=1.12, 95% CI=0.97-1.30) and adenocarcinoma (OR=1.19, 95% CI=1.05-1.35). In conclusion, increased African ancestry (or variants linked to it) contributes to the increased susceptibility of colorectal cancer in admixed Latin American population.European Journal of Human Genetics advance online publication, 12 February 2014; doi:10.1038/ejhg.2013.310.
Original languageEnglish
Pages (from-to)1208-1216
JournalEuropean Journal of Human Genetics
Issue number10
Early online date12 Feb 2014
Publication statusPublished - 12 Feb 2014

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