Genetic aspects of the polymodally distributed sulphoxidation of S-carboxymethyl-L-cysteine in man

S C Mitchell, R H Waring, C S Haley, J R Idle, R L Smith

Research output: Contribution to journalArticlepeer-review

Abstract

Interindividual variation in the sulphoxidation of S-carboxymethyl-L-cysteine (750 mg p.o.) was investigated in 200 healthy volunteers. Nearly a 100-fold difference was observed between individuals with respect to the amount of sulphoxide metabolites detected in their 0-8 h urine (0.6 to 59.1% recovery). Such a difference was shown to be reproducible over several months in 40 subjects who spanned the entire range of capacities. Cumulative plots and maximum likelihood analysis of the distribution indicated that a bimodal model was most probable. Analysis of pedigree data obtained from 12 families suggested a genetic effect with overlying environmental influences.
Original languageEnglish
Pages (from-to)507-21
Number of pages15
JournalBritish Journal of Clinical Pharmacology
Volume18
Issue number4
DOIs
Publication statusPublished - Oct 1984

Keywords

  • Adolescent
  • Adult
  • Carbocysteine
  • Contraceptives, Oral
  • Cysteine
  • Female
  • Humans
  • Individuality
  • Male
  • Penicillamine
  • Polymorphism, Genetic
  • Sulfoxides

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