Genetic background of early life telomere length and association with dairy cow longevity

Joanna Ilska; Androniki Psifidi; Luise Seeker; Christopher Whitelaw; M. Coffey; Daniel Nussey; Georgios Banos

Genetic background of early life telomere length and association with dairy cow longevity

Joanna Ilska, Androniki Psifidi, Luise Seeker, Christopher Whitelaw, M. Coffey, Daniel Nussey, Georgios Banos

Research output: Contribution to conference › Paper › peer-review

Abstract

Involuntary culling is a major cause of economic loss in dairy cows. Here we examine the genetic background of telomere length (TL) and its association with dairy cow longevity, using the largest dataset of TL measurement in livestock species. Heritability of TL at birth (TLB) was moderate and significant. A genome-wide association study (GWAS) revealed three suggestive genome-wide significant SNPs on chromosomes 1 and 23 affecting TLB. Significant phenotypic correlations of TLB with a range of longevity traits and a significant genetic correlation with survival to 48 months of age were also estimated. Keywords: longevity, dairy, telomere length, biomarker, GWAS

Original language	English
Publication status	Published - 11 Feb 2018
Event	11th World Congress on Genetics Applied to Livestock Production - Aotea Centre, Auckland, New Zealand Duration: 11 Feb 2018 → 16 Feb 2018

Conference

Conference	11th World Congress on Genetics Applied to Livestock Production
Abbreviated title	WCGALP
Country/Territory	New Zealand
City	Auckland
Period	11/02/18 → 16/02/18

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genetic-background-early-life-telomere-length-and-association-dairy-cow-longevityFinal published version, 184 KBLicence: Creative Commons: Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND)

http://www.wcgalp.org/proceedings/2018/genetic-background-early-life-telomere-length-and-association-dairy-cow-longevity

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Ilska, J., Psifidi, A., Seeker, L., Whitelaw, C., Coffey, M., Nussey, D., & Banos, G. (2018). Genetic background of early life telomere length and association with dairy cow longevity. Paper presented at 11th World Congress on Genetics Applied to Livestock Production, Auckland, New Zealand. http://www.wcgalp.org/proceedings/2018/genetic-background-early-life-telomere-length-and-association-dairy-cow-longevity

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title = "Genetic background of early life telomere length and association with dairy cow longevity",

abstract = "Involuntary culling is a major cause of economic loss in dairy cows. Here we examine the genetic background of telomere length (TL) and its association with dairy cow longevity, using the largest dataset of TL measurement in livestock species. Heritability of TL at birth (TLB) was moderate and significant. A genome-wide association study (GWAS) revealed three suggestive genome-wide significant SNPs on chromosomes 1 and 23 affecting TLB. Significant phenotypic correlations of TLB with a range of longevity traits and a significant genetic correlation with survival to 48 months of age were also estimated. Keywords: longevity, dairy, telomere length, biomarker, GWAS",

author = "Joanna Ilska and Androniki Psifidi and Luise Seeker and Christopher Whitelaw and M. Coffey and Daniel Nussey and Georgios Banos",

year = "2018",

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note = "11th World Congress on Genetics Applied to Livestock Production, WCGALP ; Conference date: 11-02-2018 Through 16-02-2018",

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Ilska, J, Psifidi, A, Seeker, L, Whitelaw, C, Coffey, M, Nussey, D & Banos, G 2018, 'Genetic background of early life telomere length and association with dairy cow longevity', Paper presented at 11th World Congress on Genetics Applied to Livestock Production, Auckland, New Zealand, 11/02/18 - 16/02/18. <http://www.wcgalp.org/proceedings/2018/genetic-background-early-life-telomere-length-and-association-dairy-cow-longevity>

TY - CONF

T1 - Genetic background of early life telomere length and association with dairy cow longevity

AU - Ilska, Joanna

AU - Psifidi, Androniki

AU - Seeker, Luise

AU - Whitelaw, Christopher

AU - Coffey, M.

AU - Nussey, Daniel

AU - Banos, Georgios

PY - 2018/2/11

Y1 - 2018/2/11

N2 - Involuntary culling is a major cause of economic loss in dairy cows. Here we examine the genetic background of telomere length (TL) and its association with dairy cow longevity, using the largest dataset of TL measurement in livestock species. Heritability of TL at birth (TLB) was moderate and significant. A genome-wide association study (GWAS) revealed three suggestive genome-wide significant SNPs on chromosomes 1 and 23 affecting TLB. Significant phenotypic correlations of TLB with a range of longevity traits and a significant genetic correlation with survival to 48 months of age were also estimated. Keywords: longevity, dairy, telomere length, biomarker, GWAS

AB - Involuntary culling is a major cause of economic loss in dairy cows. Here we examine the genetic background of telomere length (TL) and its association with dairy cow longevity, using the largest dataset of TL measurement in livestock species. Heritability of TL at birth (TLB) was moderate and significant. A genome-wide association study (GWAS) revealed three suggestive genome-wide significant SNPs on chromosomes 1 and 23 affecting TLB. Significant phenotypic correlations of TLB with a range of longevity traits and a significant genetic correlation with survival to 48 months of age were also estimated. Keywords: longevity, dairy, telomere length, biomarker, GWAS

M3 - Paper

T2 - 11th World Congress on Genetics Applied to Livestock Production

Y2 - 11 February 2018 through 16 February 2018

ER -

Genetic background of early life telomere length and association with dairy cow longevity

Abstract

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