Genetic causality in schizophrenia and bipolar disorder: out with the old and in with the new

D. Porteous

Research output: Contribution to journalLiterature reviewpeer-review

Abstract

Schizophrenia (SZ) and bipolar disorder are highly heritable forms of major mental illness. Great hopes were held out for a major breakthrough with the advent of genome wide association studies, but to date there have been no obvious low hanging fruit. A richer harvest of strong candidates has however emerged from molecular cytogenetics and copy number variant mapping strategies promise to add more. Both strategies identify gene mutations, paving a direct path to biological studies and tests of causality. Risk genes and convergent biological pathways common to both disorders are being revealed, offering hope for a better understanding of aetiological factors and for the development of biomarkers to aid in diagnosis and prognosis.
Original languageEnglish
Pages (from-to)229-234
Number of pages6
JournalCurrent Opinion in Genetics and Development
Volume18
Issue number3
DOIs
Publication statusPublished - Jun 2008

Keywords

  • Disease Outbreaks
  • Great Britain/epidemiology
  • Hepacivirus/ genetics
  • Hepatitis C/ epidemiology/virology
  • Humans
  • Phylogeny
  • Substance Abuse, Intravenous/ complications
  • Time Factors

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