Genetic comparison of a Croatian isolate and CEPH European founders

Pau Navarro, Véronique Vitart, Caroline Hayward, Albert Tenesa, Lina Zgaga, Danica Juricic, Ozren Polasek, Nicholas D Hastie, Igor Rudan, Harry Campbell, Alan F Wright, Chris S Haley, Sara A Knott

Research output: Contribution to journalArticlepeer-review


Human isolates have been postulated as a good resource for the identification of QTL due to reduced genetic diversity and a more homogeneous environment. Isolates may also have increased linkage disequilibrium (LD) due to small effective population size and, either loss or increase in frequency of alleles that are rare in the general population from which they originate. Here we investigate the difference in allele and genotype frequencies, LD and homozygous tracts between an isolate-several villages from the island of Vis in Croatia-and an outbred population of European origin: the Hapmap CEPH founders. Using the HumanHap300 v1 Genotyping BeadChip, we show that our population does not differ greatly from the reference CEU outbred population despite having a slightly higher proportion of monomorphic loci, a slightly higher long-range LD, and a greater proportion of individuals with long homozygous tracts. We conclude that genotyping arrays should perform equally well in our isolate as in outbred European populations for disease mapping studies and that SNP-trait associations discovered in our well-characterized Croatian isolate should be valid in the general European population from which they descend.
Original languageEnglish
Pages (from-to)140-5
Number of pages6
JournalGenetic Epidemiology
Issue number2
Publication statusPublished - Feb 2010


  • linkage disequilibrium
  • mapping
  • population isolate


Dive into the research topics of 'Genetic comparison of a Croatian isolate and CEPH European founders'. Together they form a unique fingerprint.

Cite this