Genetic control of resistance to trypanosomiasis

S J Kemp, A Darvasi, M Soller, A J Teale

Research output: Contribution to journalArticlepeer-review

Abstract

To map the genetic sources of trypanotolerance in mice, a linkage analysis of survival following trypanosome challenge was performed by selective genotyping in a large F2 population produced by crossing the resistant C57BL/6 and susceptible BALB/c inbred mouse lines. We report evidence of a chromosomal region of large effect, possibly comprising more than one resistance locus, on Chromosome 17; and of further loci on Chromosomes 1 and 5. Together, these genes can account for all of the difference between the mean parental phenotypes.

Original languageEnglish
Pages (from-to)239-43
Number of pages5
JournalVeterinary Immunology and Immunopathology
Volume54
Issue number1-4
Publication statusPublished - Nov 1996

Keywords

  • Animals
  • Cell Line
  • Chromosome Mapping
  • Genetic Linkage
  • Immunity, Innate
  • Mice
  • Mice, Inbred BALB C
  • Mice, Inbred C57BL
  • Species Specificity
  • Trypanosomiasis

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