Genetic control of the innate immune response

Christine A Wells; Timothy Ravasi; Geoffrey J Faulkner; Piero Carninci; Yasushi Okazaki; Yoshihide Hayashizaki; Matthew Sweet; Brandon J Wainwright; David A Hume

doi:10.1186/1471-2172-4-5

Genetic control of the innate immune response

Christine A Wells, Timothy Ravasi, Geoffrey J Faulkner, Piero Carninci, Yasushi Okazaki, Yoshihide Hayashizaki, Matthew Sweet, Brandon J Wainwright, David A Hume

Royal (Dick) School of Veterinary Studies

Research output: Contribution to journal › Article › peer-review

Abstract

Susceptibility to infectious diseases is directed, in part, by the interaction between the invading pathogen and host macrophages. This study examines the influence of genetic background on host-pathogen interactions, by assessing the transcriptional responses of macrophages from five inbred mouse strains to lipopolysaccharide (LPS), a major determinant of responses to gram-negative microorganisms.

Original language	English
Pages (from-to)	5
Journal	BMC Immunology
Volume	4
DOIs	https://doi.org/10.1186/1471-2172-4-5
Publication status	Published - 26 Jun 2003

Keywords / Materials (for Non-textual outputs)

Animals
Cell Differentiation
Cell Division
Cells, Cultured
Chromosome Mapping
Gene Expression Profiling
Immunity, Innate
Inflammation
Kinetics
Lipopolysaccharides
Macrophage Activation
Macrophages
Membrane Glycoproteins
Mice
Mice, Inbred BALB C
Mice, Inbred C3H
Mice, Inbred CBA
Mice, Inbred DBA
Mutation
Receptors, Cell Surface
Species Specificity
Toll-Like Receptor 4
Toll-Like Receptors
Transcription, Genetic

Access to Document

10.1186/1471-2172-4-5

Genetic control of the innate immune response
003 Wells et al; licensee BioMed Central Ltd. This is an Open Access articl e: verbatim copying and re distribution of this ar ticle are permitted in all media for any purpose, provided this notice is preserved along with the article's original URL
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Cite this

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abstract = "Susceptibility to infectious diseases is directed, in part, by the interaction between the invading pathogen and host macrophages. This study examines the influence of genetic background on host-pathogen interactions, by assessing the transcriptional responses of macrophages from five inbred mouse strains to lipopolysaccharide (LPS), a major determinant of responses to gram-negative microorganisms.",

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T1 - Genetic control of the innate immune response

AU - Wells, Christine A

AU - Ravasi, Timothy

AU - Faulkner, Geoffrey J

AU - Carninci, Piero

AU - Okazaki, Yasushi

AU - Hayashizaki, Yoshihide

AU - Sweet, Matthew

AU - Wainwright, Brandon J

AU - Hume, David A

PY - 2003/6/26

Y1 - 2003/6/26

N2 - Susceptibility to infectious diseases is directed, in part, by the interaction between the invading pathogen and host macrophages. This study examines the influence of genetic background on host-pathogen interactions, by assessing the transcriptional responses of macrophages from five inbred mouse strains to lipopolysaccharide (LPS), a major determinant of responses to gram-negative microorganisms.

AB - Susceptibility to infectious diseases is directed, in part, by the interaction between the invading pathogen and host macrophages. This study examines the influence of genetic background on host-pathogen interactions, by assessing the transcriptional responses of macrophages from five inbred mouse strains to lipopolysaccharide (LPS), a major determinant of responses to gram-negative microorganisms.

KW - Animals

KW - Cell Differentiation

KW - Cell Division

KW - Cells, Cultured

KW - Chromosome Mapping

KW - Gene Expression Profiling

KW - Immunity, Innate

KW - Inflammation

KW - Kinetics

KW - Lipopolysaccharides

KW - Macrophage Activation

KW - Macrophages

KW - Membrane Glycoproteins

KW - Mice

KW - Mice, Inbred BALB C

KW - Mice, Inbred C3H

KW - Mice, Inbred CBA

KW - Mice, Inbred DBA

KW - Mutation

KW - Receptors, Cell Surface

KW - Species Specificity

KW - Toll-Like Receptor 4

KW - Toll-Like Receptors

KW - Transcription, Genetic

U2 - 10.1186/1471-2172-4-5

DO - 10.1186/1471-2172-4-5

M3 - Article

C2 - 12826024

SN - 1471-2172

VL - 4

SP - 5

JO - BMC Immunology

JF - BMC Immunology

ER -

Genetic control of the innate immune response

Abstract

Keywords / Materials (for Non-textual outputs)

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