Genetic control of the innate immune response

Christine A Wells, Timothy Ravasi, Geoffrey J Faulkner, Piero Carninci, Yasushi Okazaki, Yoshihide Hayashizaki, Matthew Sweet, Brandon J Wainwright, David A Hume

Research output: Contribution to journalArticlepeer-review


Susceptibility to infectious diseases is directed, in part, by the interaction between the invading pathogen and host macrophages. This study examines the influence of genetic background on host-pathogen interactions, by assessing the transcriptional responses of macrophages from five inbred mouse strains to lipopolysaccharide (LPS), a major determinant of responses to gram-negative microorganisms.
Original languageEnglish
Pages (from-to)5
JournalBMC Immunology
Publication statusPublished - 26 Jun 2003


  • Animals
  • Cell Differentiation
  • Cell Division
  • Cells, Cultured
  • Chromosome Mapping
  • Gene Expression Profiling
  • Immunity, Innate
  • Inflammation
  • Kinetics
  • Lipopolysaccharides
  • Macrophage Activation
  • Macrophages
  • Membrane Glycoproteins
  • Mice
  • Mice, Inbred BALB C
  • Mice, Inbred C3H
  • Mice, Inbred CBA
  • Mice, Inbred DBA
  • Mutation
  • Receptors, Cell Surface
  • Species Specificity
  • Toll-Like Receptor 4
  • Toll-Like Receptors
  • Transcription, Genetic

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