Genetic determinants of the epigenome in development and cancer

Bird Adrian*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

Abstract

Although we have detailed maps of epigenetic marks on DNA and chromatin for many cell types and disease states, the origin and significance of these patterns is incompletely understood. Deregulation of the epigenome is a frequent accompaniment to cancer, and it is therefore important that we learn how it contributes to tumour formation. Here it is proposed that the roles of DNA sequence signals as determinants of the epigenome have been un-derappreciated. Taking as a paradigm the part played by the dinucleotide CpG in regulating gene expression via its effects on the epigenome, it is suggested that factors recognising other short, frequent sequence motifs also recruit chromatin modifying enzymes in response to DNA sequence. A screen for factors of this kind promises to aid our understanding of the mechanisms by which gene activity is globally regulated.

Original languageEnglish
Article numberw14523
JournalSwiss medical weekly
Volume147
Issue number41-42
DOIs
Publication statusPublished - 12 Oct 2017

Keywords

  • CpG islands
  • DNA methylation
  • epigenome

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