Genetic evidence for a pathogenic role for the vitamin D3 metabolizing enzyme CYP24A1 in multiple sclerosis

Adaikalavan Ramasamy, Daniah Trabzuni, Paola Forabosco, Colin Smith, Robert Walker, Allissa Dillman, Sigurlaug Sveinbjornsdottir, John Hardy, Michael E. Weale, Mina Ryten

Research output: Contribution to journalArticlepeer-review

Abstract

Multiple sclerosis (MS) is a common disease of the central nervous system and a major cause of disability amongst young adults. Genome-wide association studies have identified many novel susceptibility loci including rs2248359. We hypothesized that genotypes of this locus could increase the risk of MS by regulating expression of neighboring gene, CYP24A1 which encodes the enzyme responsible for initiating degradation of 1,25-dihydroxyvitamin D3.
Original languageEnglish
Pages (from-to)211-219
JournalMultiple Sclerosis and Related Disorders
Volume3
Issue number2
DOIs
Publication statusPublished - Mar 2014

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