Genetic mapping of quantitative trait loci for growth and fatness in pigs

L Andersson; C S Haley; H Ellegren; S A Knott; M Johansson; K Andersson; L Andersson-Eklund; I Edfors-Lilja; M Fredholm; I Hansson

Genetic mapping of quantitative trait loci for growth and fatness in pigs

L Andersson, C S Haley, H Ellegren, S A Knott, M Johansson, K Andersson, L Andersson-Eklund, I Edfors-Lilja, M Fredholm, I Hansson

Research output: Contribution to journal › Article › peer-review

Abstract

The European wild boar was crossed with the domesticated Large White pig to genetically dissect phenotypic differences between these populations for growth and fat deposition. The most important effects were clustered on chromosome 4, with a single region accounting for a large part of the breed difference in growth rate, fatness, and length of the small intestine. The study is an advance in genome analyses and documents the usefulness of crosses between divergent outbred populations for the detection and characterization of quantitative trait loci. The genetic mapping of a major locus for fat deposition in the pig could have implications for understanding human obesity.

Original language	English
Pages (from-to)	1771-4
Number of pages	4
Journal	Science
Volume	263
Issue number	5154
Publication status	Published - 25 Mar 1994

Keywords / Materials (for Non-textual outputs)

Adipose Tissue
Animals
Chromosome Mapping
Crosses, Genetic
Disease Models, Animal
Female
Genes
Genetic Markers
Humans
Intestine, Small
Likelihood Functions
Male
Obesity
Phenotype
Swine

Cite this

@article{c4e7ce142c5b4e05824a47d4f3f6c138,

title = "Genetic mapping of quantitative trait loci for growth and fatness in pigs",

abstract = "The European wild boar was crossed with the domesticated Large White pig to genetically dissect phenotypic differences between these populations for growth and fat deposition. The most important effects were clustered on chromosome 4, with a single region accounting for a large part of the breed difference in growth rate, fatness, and length of the small intestine. The study is an advance in genome analyses and documents the usefulness of crosses between divergent outbred populations for the detection and characterization of quantitative trait loci. The genetic mapping of a major locus for fat deposition in the pig could have implications for understanding human obesity.",

keywords = "Adipose Tissue, Animals, Chromosome Mapping, Crosses, Genetic, Disease Models, Animal, Female, Genes, Genetic Markers, Humans, Intestine, Small, Likelihood Functions, Male, Obesity, Phenotype, Swine",

author = "L Andersson and Haley, {C S} and H Ellegren and Knott, {S A} and M Johansson and K Andersson and L Andersson-Eklund and I Edfors-Lilja and M Fredholm and I Hansson",

year = "1994",

month = mar,

day = "25",

language = "English",

volume = "263",

pages = "1771--4",

journal = "Science",

issn = "0036-8075",

publisher = "AMER ASSOC ADVANCEMENT SCIENCE",

number = "5154",

}

TY - JOUR

T1 - Genetic mapping of quantitative trait loci for growth and fatness in pigs

AU - Andersson, L

AU - Haley, C S

AU - Ellegren, H

AU - Knott, S A

AU - Johansson, M

AU - Andersson, K

AU - Andersson-Eklund, L

AU - Edfors-Lilja, I

AU - Fredholm, M

AU - Hansson, I

PY - 1994/3/25

Y1 - 1994/3/25

N2 - The European wild boar was crossed with the domesticated Large White pig to genetically dissect phenotypic differences between these populations for growth and fat deposition. The most important effects were clustered on chromosome 4, with a single region accounting for a large part of the breed difference in growth rate, fatness, and length of the small intestine. The study is an advance in genome analyses and documents the usefulness of crosses between divergent outbred populations for the detection and characterization of quantitative trait loci. The genetic mapping of a major locus for fat deposition in the pig could have implications for understanding human obesity.

AB - The European wild boar was crossed with the domesticated Large White pig to genetically dissect phenotypic differences between these populations for growth and fat deposition. The most important effects were clustered on chromosome 4, with a single region accounting for a large part of the breed difference in growth rate, fatness, and length of the small intestine. The study is an advance in genome analyses and documents the usefulness of crosses between divergent outbred populations for the detection and characterization of quantitative trait loci. The genetic mapping of a major locus for fat deposition in the pig could have implications for understanding human obesity.

KW - Adipose Tissue

KW - Animals

KW - Chromosome Mapping

KW - Crosses, Genetic

KW - Disease Models, Animal

KW - Female

KW - Genes

KW - Genetic Markers

KW - Humans

KW - Intestine, Small

KW - Likelihood Functions

KW - Male

KW - Obesity

KW - Phenotype

KW - Swine

M3 - Article

C2 - 8134840

SN - 0036-8075

VL - 263

SP - 1771

EP - 1774

JO - Science

JF - Science

IS - 5154

ER -

Genetic mapping of quantitative trait loci for growth and fatness in pigs

Abstract

Keywords / Materials (for Non-textual outputs)

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