Genetic prediction of complex traits: integrating infinitesimal and marked genetic effects

Clément Carré, Fabrice Gamboa, David Cros, John Michael Hickey, Gregor Gorjanc, Eduardo Manfredi

Research output: Contribution to journalArticlepeer-review

Abstract

Genetic prediction for complex traits is usually based on models including individual (infinitesimal) or marker effects. Here, we concentrate on models including both the individual and the marker effects. In particular, we develop a "Mendelian segregation" model combining infinitesimal effects for base individuals and realized Mendelian sampling in descendants described by the available DNA data. The model is illustrated with an example and the analyses of a public simulated data file. Further, the potential contribution of such models is assessed by simulation. Accuracy, measured as the correlation between true (simulated) and predicted genetic values, was similar for all models compared under different genetic backgrounds. As expected, the segregation model is worthwhile when markers capture a low fraction of total genetic variance.
Original languageEnglish
Pages (from-to)239-246
Number of pages8
JournalGenetica
Volume141
DOIs
Publication statusPublished - 30 Jun 2013

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