Genetic prion disease: the EUROCJD experience

Gábor G Kovács, Maria Puopolo, Anna Ladogana, Maurizio Pocchiari, Herbert Budka, Cornelia van Duijn, Steven J Collins, Alison Boyd, Antonio Giulivi, Mike Coulthart, Nicole Delasnerie-Laupretre, Jean Philippe Brandel, Inga Zerr, Hans A Kretzschmar, Jesus de Pedro-Cuesta, Miguel Calero-Lara, Markus Glatzel, Adriano Aguzzi, Matthew Bishop, Richard KnightGirma Belay, Robert Will, Eva Mitrova, EUROCJD

Research output: Contribution to journalArticlepeer-review


A total of 10-15% of human transmissible spongiform encephalopathies (TSEs) or prion diseases are characterised by disease-specific mutations in the prion protein gene (PRNP). We examined the phenotype, distribution, and frequency of genetic TSEs (gTSEs) in different countries/geographical regions. We collected standardised data on gTSEs between 1993 and 2002 in the framework of the EUROCJD collaborative surveillance project. Our results show that clinicopathological phenotypes include genetic Creutzfeldt-Jakob disease (gCJD), fatal familial insomnia (FFI), and Gerstmann-Sträussler-Scheinker disease (GSS). Genetic TSE patients with insert mutation in the PRNP represent a separate group. Point and insertional mutations in the PRNP gene varies significantly in frequency between countries. The commonest mutation is E200K. Absence of a positive family history is noted in a significant proportion of cases in all mutation types (12-88%). FFI and GSS patients develop disease earlier than gCJD. Base pair insertions associated with the Creutzfeldt-Jakob disease (CJD) phenotype, GSS, and FFI cases have a longer duration of illness compared to cases with point mutations and gCJD. Cerebrospinal fluid 14-3-3 immunoassay, EEG, and MRI brain scan are useful in the diagnosis of CJD with point mutations, but are less sensitive in the other forms. Given the low prevalence of family history, the term "gTSE" is preferable to "familial TSE". Application of genetic screening in clinical practice has the advantage of early diagnosis and may lead to the identification of a risk of a TSE.

Original languageEnglish
Pages (from-to)166-74
Number of pages9
JournalHuman Genetics
Issue number2
Publication statusPublished - Nov 2005


  • Adult
  • Aged
  • Aged, 80 and over
  • Amyloid
  • Brain
  • DNA Mutational Analysis
  • Europe
  • Female
  • Gene Frequency
  • Genetic Testing
  • Humans
  • Male
  • Middle Aged
  • Mutagenesis, Insertional
  • Point Mutation
  • Prevalence
  • Prion Diseases
  • Prions
  • Protein Precursors
  • Risk Factors

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