Genetic prognostic markers in colorectal cancer

R S Houlston, I P Tomlinson

Research output: Contribution to journalReview articlepeer-review

Abstract / Description of output

The contribution of molecular genetics to colorectal cancer has been restricted largely to relatively rare inherited tumours and to the detection of germline mutations predisposing to these cancers. However, much is now also known about somatic events leading to colorectal cancer. A number of studies has been undertaken examining possible relations between genetic features and prognostic indices. While many of these studies are small and inconclusive, it is clear that a number of different pathways exist for the development of this cancer and some molecular characteristics correlate with clinicopathological features. With the advent of methods for the rapid genotyping of large numbers of colorectal cancers, it should be possible to evaluate fully the clinical usefulness of colorectal cancer genotypes through multivariate analyses.

Original languageEnglish
Pages (from-to)281-8
Number of pages8
JournalJournal of clinical pathology-Molecular pathology
Volume50
Issue number6
DOIs
Publication statusPublished - Dec 1997

Keywords / Materials (for Non-textual outputs)

  • Cell Transformation, Neoplastic/genetics
  • Colorectal Neoplasms/genetics
  • Disease Progression
  • Humans
  • Mutation
  • Prognosis

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