Genetic regulation of host responses to group A streptococcus in mice

Eva Medina, Andreas Lengeling

Research output: Contribution to journalArticlepeer-review

Abstract

The group A streptococci (GAS, Streptococcus pyogenes) are important human pathogens which can cause a variety of diseases, ranging from mild infections to very severe invasive diseases. In recent years, evidence has been accumulated that host genetic factors have a major influence on the outcome of streptococcal infections. Variability in the degree of susceptibility of different inbred mouse strains to infection with GAS has demonstrated that the host genetic background largely determines the susceptibility of mice to this pathogen. This information is particularly useful for studying the immune mechanisms underlying disease susceptibility in mice, and provides an entry point for the identification of host defence loci. This paper reviews the recent advances in the characterisation of pathogenic mechanisms associated with the development of GAS-induced septic shock in the mouse model and outlines the current knowledge regarding the genetic control of immune responses to Group A streptococcus in mice.
Original languageEnglish
Pages (from-to)248-57
Number of pages10
JournalBriefings in functional genomics & proteomics
Volume4
Issue number3
Publication statusPublished - 2005

Keywords

  • Animals
  • Disease Susceptibility
  • Gene Expression Regulation
  • Genetic Predisposition to Disease
  • HLA Antigens/genetics
  • Humans
  • Inflammation
  • Killer Cells, Natural/metabolism
  • Macrophages/metabolism
  • Mice
  • Models, Genetic
  • Rheumatic Fever/genetics
  • Species Specificity
  • Streptococcus pyogenes/metabolism
  • Superantigens
  • Time Factors
  • Transgenes

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