Genetic risk factors for ischaemic stroke and its subtypes (the METASTROKE collaboration): a meta-analysis of genome-wide association studies

Australian Stroke Genetics Collaborative, Wellcome Trust Case Control Consortium 2 (WTCCC2); Matthew Traylor; Martin Farrall; Elizabeth G Holliday; Catherine Sudlow; Jemma C Hopewell; Yu-Ching Cheng; Myriam Fornage; M Arfan Ikram; Rainer Malik; Steve Bevan; Unnur Thorsteinsdottir; Mike A Nalls; Wt Longstreth; Kerri L Wiggins; Sunaina Yadav; Eugenio A Parati; Anita L Destefano; Bradford B Worrall; Steven J Kittner; Muhammad Saleem Khan; Alex P Reiner; Anna Helgadottir; Sefanja Achterberg; Israel Fernandez-Cadenas; Sherine Abboud; Reinhold Schmidt; Matthew Walters; Wei-Min Chen; E Bernd Ringelstein; Martin O'Donnell; Weang Kee Ho; Joanna Pera; Robin Lemmens; Bo Norrving; Peter Higgins; Marianne Benn; Michele Sale; Gregor Kuhlenbäumer; Alexander S F Doney; Astrid M Vicente; Hossein Delavaran; Ale Algra; Gail Davies; Sofia A Oliveira; Colin N A Palmer; Ian Deary; Helena Schmidt; Massimo Pandolfo; Joan Montaner; Cara Carty

doi:10.1016/S1474-4422(12)70234-X

Genetic risk factors for ischaemic stroke and its subtypes (the METASTROKE collaboration): a meta-analysis of genome-wide association studies

Australian Stroke Genetics Collaborative, Wellcome Trust Case Control Consortium 2 (WTCCC2), Matthew Traylor, Martin Farrall, Elizabeth G Holliday, Catherine Sudlow, Jemma C Hopewell, Yu-Ching Cheng, Myriam Fornage, M Arfan Ikram, Rainer Malik, Steve Bevan, Unnur Thorsteinsdottir, Mike A Nalls, Wt Longstreth, Kerri L Wiggins, Sunaina Yadav, Eugenio A Parati, Anita L Destefano, Bradford B Worrall, Steven J KittnerMuhammad Saleem Khan, Alex P Reiner, Anna Helgadottir, Sefanja Achterberg, Israel Fernandez-Cadenas, Sherine Abboud, Reinhold Schmidt, Matthew Walters, Wei-Min Chen, E Bernd Ringelstein, Martin O'Donnell, Weang Kee Ho, Joanna Pera, Robin Lemmens, Bo Norrving, Peter Higgins, Marianne Benn, Michele Sale, Gregor Kuhlenbäumer, Alexander S F Doney, Astrid M Vicente, Hossein Delavaran, Ale Algra, Gail Davies, Sofia A Oliveira, Colin N A Palmer, Ian Deary, Helena Schmidt, Massimo Pandolfo, Joan Montaner, Cara Carty

Research output: Contribution to journal › Article › peer-review

Abstract

Various genome-wide association studies (GWAS) have been done in ischaemic stroke, identifying a few loci associated with the disease, but sample sizes have been 3500 cases or less. We established the METASTROKE collaboration with the aim of validating associations from previous GWAS and identifying novel genetic associations through meta-analysis of GWAS datasets for ischaemic stroke and its subtypes.

Original language	English
Pages (from-to)	951-62
Number of pages	12
Journal	Lancet Neurology
Volume	11
Issue number	11
DOIs	https://doi.org/10.1016/S1474-4422(12)70234-X
Publication status	Published - Nov 2012

Keywords / Materials (for Non-textual outputs)

Brain Ischemia
Databases, Genetic
Genetic Predisposition to Disease
Genome-Wide Association Study
Humans
Risk Factors
Stroke

Access to Document

10.1016/S1474-4422(12)70234-X

Genetic risk factors for ischaemic stroke and its subtypes (the METASTROKE Collaboration) a meta-analysis of genome-wide association studies
Available under Open Access
Final published version, 1.23 MB

http://www.sciencedirect.com/science/article/pii/S147444221270234X

Centre for Cognitive Ageing and Cognitive Epidemiology Phase 2.
Maclullich, A. (Principal Investigator)
1/09/13 → 31/08/19
Project: Research
Disconnected Mind [Phase 2]
Wardlaw, J. (Principal Investigator)
UK-based charities
1/01/11 → 31/03/16
Project: Research
A genome wide association study of non pathological cognitive ageing
Deary, I. (Principal Investigator), Porteous, D. (Co-investigator) & Tenesa, A. (Co-investigator)
BBSRC
1/09/08 → 31/08/10
Project: Research

Cite this

Australian Stroke Genetics Collaborative, Wellcome Trust Case Control Consortium 2 (WTCCC2), Traylor, M., Farrall, M., Holliday, E. G., Sudlow, C., Hopewell, J. C., Cheng, Y.-C., Fornage, M., Ikram, M. A., Malik, R., Bevan, S., Thorsteinsdottir, U., Nalls, M. A., Longstreth, W., Wiggins, K. L., Yadav, S., Parati, E. A., Destefano, A. L., Worrall, B. B., ... Carty, C. (2012). Genetic risk factors for ischaemic stroke and its subtypes (the METASTROKE collaboration): a meta-analysis of genome-wide association studies. Lancet Neurology, 11(11), 951-62. https://doi.org/10.1016/S1474-4422(12)70234-X

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title = "Genetic risk factors for ischaemic stroke and its subtypes (the METASTROKE collaboration): a meta-analysis of genome-wide association studies",

abstract = "Various genome-wide association studies (GWAS) have been done in ischaemic stroke, identifying a few loci associated with the disease, but sample sizes have been 3500 cases or less. We established the METASTROKE collaboration with the aim of validating associations from previous GWAS and identifying novel genetic associations through meta-analysis of GWAS datasets for ischaemic stroke and its subtypes.",

keywords = "Brain Ischemia, Databases, Genetic, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, Risk Factors, Stroke",

author = "{Australian Stroke Genetics Collaborative, Wellcome Trust Case Control Consortium 2 (WTCCC2)} and Matthew Traylor and Martin Farrall and Holliday, {Elizabeth G} and Catherine Sudlow and Hopewell, {Jemma C} and Yu-Ching Cheng and Myriam Fornage and Ikram, {M Arfan} and Rainer Malik and Steve Bevan and Unnur Thorsteinsdottir and Nalls, {Mike A} and Wt Longstreth and Wiggins, {Kerri L} and Sunaina Yadav and Parati, {Eugenio A} and Destefano, {Anita L} and Worrall, {Bradford B} and Kittner, {Steven J} and Khan, {Muhammad Saleem} and Reiner, {Alex P} and Anna Helgadottir and Sefanja Achterberg and Israel Fernandez-Cadenas and Sherine Abboud and Reinhold Schmidt and Matthew Walters and Wei-Min Chen and Ringelstein, {E Bernd} and Martin O'Donnell and Ho, {Weang Kee} and Joanna Pera and Robin Lemmens and Bo Norrving and Peter Higgins and Marianne Benn and Michele Sale and Gregor Kuhlenb{\"a}umer and Doney, {Alexander S F} and Vicente, {Astrid M} and Hossein Delavaran and Ale Algra and Gail Davies and Oliveira, {Sofia A} and Palmer, {Colin N A} and Ian Deary and Helena Schmidt and Massimo Pandolfo and Joan Montaner and Cara Carty",

year = "2012",

month = nov,

doi = "10.1016/S1474-4422(12)70234-X",

language = "English",

volume = "11",

pages = "951--62",

journal = "Lancet Neurology",

issn = "1474-4422",

publisher = "Elsevier",

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}

Australian Stroke Genetics Collaborative, Wellcome Trust Case Control Consortium 2 (WTCCC2), Traylor, M, Farrall, M, Holliday, EG, Sudlow, C, Hopewell, JC, Cheng, Y-C, Fornage, M, Ikram, MA, Malik, R, Bevan, S, Thorsteinsdottir, U, Nalls, MA, Longstreth, W, Wiggins, KL, Yadav, S, Parati, EA, Destefano, AL, Worrall, BB, Kittner, SJ, Khan, MS, Reiner, AP, Helgadottir, A, Achterberg, S, Fernandez-Cadenas, I, Abboud, S, Schmidt, R, Walters, M, Chen, W-M, Ringelstein, EB, O'Donnell, M, Ho, WK, Pera, J, Lemmens, R, Norrving, B, Higgins, P, Benn, M, Sale, M, Kuhlenbäumer, G, Doney, ASF, Vicente, AM, Delavaran, H, Algra, A, Davies, G, Oliveira, SA, Palmer, CNA, Deary, I, Schmidt, H, Pandolfo, M, Montaner, J & Carty, C 2012, 'Genetic risk factors for ischaemic stroke and its subtypes (the METASTROKE collaboration): a meta-analysis of genome-wide association studies', Lancet Neurology, vol. 11, no. 11, pp. 951-62. https://doi.org/10.1016/S1474-4422(12)70234-X

Genetic risk factors for ischaemic stroke and its subtypes (the METASTROKE collaboration): a meta-analysis of genome-wide association studies. / Australian Stroke Genetics Collaborative, Wellcome Trust Case Control Consortium 2 (WTCCC2); Traylor, Matthew; Farrall, Martin et al.
In: Lancet Neurology, Vol. 11, No. 11, 11.2012, p. 951-62.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Genetic risk factors for ischaemic stroke and its subtypes (the METASTROKE collaboration)

T2 - a meta-analysis of genome-wide association studies

AU - Australian Stroke Genetics Collaborative, Wellcome Trust Case Control Consortium 2 (WTCCC2)

AU - Traylor, Matthew

AU - Farrall, Martin

AU - Holliday, Elizabeth G

AU - Sudlow, Catherine

AU - Hopewell, Jemma C

AU - Cheng, Yu-Ching

AU - Fornage, Myriam

AU - Ikram, M Arfan

AU - Malik, Rainer

AU - Bevan, Steve

AU - Thorsteinsdottir, Unnur

AU - Nalls, Mike A

AU - Longstreth, Wt

AU - Wiggins, Kerri L

AU - Yadav, Sunaina

AU - Parati, Eugenio A

AU - Destefano, Anita L

AU - Worrall, Bradford B

AU - Kittner, Steven J

AU - Khan, Muhammad Saleem

AU - Reiner, Alex P

AU - Helgadottir, Anna

AU - Achterberg, Sefanja

AU - Fernandez-Cadenas, Israel

AU - Abboud, Sherine

AU - Schmidt, Reinhold

AU - Walters, Matthew

AU - Chen, Wei-Min

AU - Ringelstein, E Bernd

AU - O'Donnell, Martin

AU - Ho, Weang Kee

AU - Pera, Joanna

AU - Lemmens, Robin

AU - Norrving, Bo

AU - Higgins, Peter

AU - Benn, Marianne

AU - Sale, Michele

AU - Kuhlenbäumer, Gregor

AU - Doney, Alexander S F

AU - Vicente, Astrid M

AU - Delavaran, Hossein

AU - Algra, Ale

AU - Davies, Gail

AU - Oliveira, Sofia A

AU - Palmer, Colin N A

AU - Deary, Ian

AU - Schmidt, Helena

AU - Pandolfo, Massimo

AU - Montaner, Joan

AU - Carty, Cara

PY - 2012/11

Y1 - 2012/11

N2 - Various genome-wide association studies (GWAS) have been done in ischaemic stroke, identifying a few loci associated with the disease, but sample sizes have been 3500 cases or less. We established the METASTROKE collaboration with the aim of validating associations from previous GWAS and identifying novel genetic associations through meta-analysis of GWAS datasets for ischaemic stroke and its subtypes.

AB - Various genome-wide association studies (GWAS) have been done in ischaemic stroke, identifying a few loci associated with the disease, but sample sizes have been 3500 cases or less. We established the METASTROKE collaboration with the aim of validating associations from previous GWAS and identifying novel genetic associations through meta-analysis of GWAS datasets for ischaemic stroke and its subtypes.

KW - Brain Ischemia

KW - Databases, Genetic

KW - Genetic Predisposition to Disease

KW - Genome-Wide Association Study

KW - Humans

KW - Risk Factors

KW - Stroke

U2 - 10.1016/S1474-4422(12)70234-X

DO - 10.1016/S1474-4422(12)70234-X

M3 - Article

C2 - 23041239

SN - 1474-4422

VL - 11

SP - 951

EP - 962

JO - Lancet Neurology

JF - Lancet Neurology

IS - 11

ER -

Australian Stroke Genetics Collaborative, Wellcome Trust Case Control Consortium 2 (WTCCC2), Traylor M, Farrall M, Holliday EG, Sudlow C, Hopewell JC et al. Genetic risk factors for ischaemic stroke and its subtypes (the METASTROKE collaboration): a meta-analysis of genome-wide association studies. Lancet Neurology. 2012 Nov;11(11):951-62. doi: 10.1016/S1474-4422(12)70234-X

Genetic risk factors for ischaemic stroke and its subtypes (the METASTROKE collaboration): a meta-analysis of genome-wide association studies

Abstract

Keywords / Materials (for Non-textual outputs)

Access to Document

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Projects

Centre for Cognitive Ageing and Cognitive Epidemiology Phase 2.

Disconnected Mind [Phase 2]

A genome wide association study of non pathological cognitive ageing

Cite this