Genetic sources of covariation among P3(00) and online performance variables in a delayed-response working memory task

M J Wright, M Luciano, N K Hansell, G M Geffen, L B Geffen, N G Martin

Research output: Contribution to journalArticlepeer-review

Abstract

Genetic and environmental sources of covariation among the P3(00) and online performance elicited in a delayed-response working memory task, and psychometric IQ assessed by the multidimensional aptitude battery, were examined in an adolescent twin sample. An association between frontal P3 latency and task performance (phenotypic r = -0.33; genotypic r = -0.49) was indicated, with genes (i.e. twin status) accounting for a large part of the covariation ( > 70%). In contrast, genes influencing P3 amplitude mediated only a small part (2%) of the total genetic variation in task performance. While task performance mediated 15% of the total genetic variation in IQ (phenotypic r = 0.22; genotypic r = 0.39) there was no association between P3 latency and IQ or P3 amplitude with IQ. The findings provide some insight into the inter-relationships among psychophysiological, performance and psychometric measures of cognitive ability, and provide support for a levels-of-processing genetic model of cognition where genes act on specific sub-components of cognitive processes. (C) 2002 Elsevier Science B.V. All rights reserved.

Original languageEnglish
Pages (from-to)183-202
Number of pages20
JournalBiological Psychology
Volume61
Issue number1-2
Publication statusPublished - Oct 2002

Keywords

  • P3 (P300)
  • working memory
  • twin study
  • event-related potentials
  • IQ
  • multivariate genetic analyses
  • individual differences
  • EVENT-RELATED POTENTIALS
  • INDIVIDUAL-DIFFERENCES
  • P300 LATENCY
  • PREFRONTAL CORTEX
  • DIZYGOTIC TWINS
  • REACTION-TIME
  • CAPACITY
  • INTELLIGENCE
  • TESTS
  • SPAN

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