Genetic variants associated with longitudinal changes in brain structure across the lifespan

IMAGEN Consortium

doi:10.1038/s41593-022-01042-4

Genetic variants associated with longitudinal changes in brain structure across the lifespan

IMAGEN Consortium

Research output: Contribution to journal › Article › peer-review

Original language	English
Pages (from-to)	421-432
Journal	Nature Neuroscience
Volume	25
Issue number	4
Early online date	5 Apr 2022
DOIs	https://doi.org/10.1038/s41593-022-01042-4
Publication status	E-pub ahead of print - 5 Apr 2022

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10.1038/s41593-022-01042-4

Brouwer Genetics brain structure lifetime NN accepted 87414_4_merged_1646080010
This is the author's peer-reviewed manuscript as accepted for publication.
Accepted author manuscript, 34.8 MB

https://www.nature.com/articles/s41593-022-01042-4

Cite this

@article{36b7af0aa8a249e596eb822a81ad34e4,

title = "Genetic variants associated with longitudinal changes in brain structure across the lifespan",

author = "{IMAGEN Consortium} and Brouwer, {Rachel M.} and Marieke Klein and Grasby, {Katrina L.} and Schnack, {Hugo G.} and Neda Jahanshad and Jalmar Teeuw and Thomopoulos, {Sophia I.} and Emma Sprooten and Franz, {Carol E.} and Nitin Gogtay and Kremen, {William S.} and Panizzon, {Matthew S.} and {Olde Loohuis}, {Loes M.} and Whelan, {Christopher D.} and Moji Aghajani and Clara Alloza and Dag Aln{\ae}s and Eric Artiges and Rosa Ayesa-arriola and Barker, {Gareth J.} and Bastin, {Mark E.} and Elisabet Blok and Erlend B{\o}en and Breukelaar, {Isabella A.} and Bright, {Joanna K.} and Buimer, {Elizabeth E. L.} and Robin B{\"u}low and Cannon, {Dara M.} and Simone Ciufolini and Crossley, {Nicolas A.} and Damatac, {Christienne G.} and Paola Dazzan and {De Mol}, {Casper L.} and {De Zwarte}, {Sonja M. C.} and Sylvane Desrivi{\`e}res and D{\'i}az-caneja, {Covadonga M.} and Doan, {Nhat Trung} and Katharina Dohm and Fr{\"o}hner, {Juliane H.} and Janik Goltermann and Antoine Grigis and Dominik Grotegerd and Han, {Laura K. M.} and Harris, {Mathew A.} and Hartman, {Catharina A.} and Heany, {Sarah J.} and Walter Heindel and Heslenfeld, {Dirk J.} and Sarah Hohmann and Bernd Ittermann and Jansen, {Philip R.} and Joost Janssen and Tianye Jia and Jiyang Jiang and Christiane Jockwitz and Temmuz Karali and Daniel Keeser and Koevoets, {Martijn G. J. C.} and Lenroot, {Rhoshel K.} and Berend Malchow and Mandl, {Ren{\'e} C. W.} and Vicente Medel and Susanne Meinert and Morgan, {Catherine A.} and M{\"u}hleisen, {Thomas W.} and Leila Nabulsi and Nils Opel and {De La Foz}, {V{\'i}ctor Ortiz-garc{\'i}a} and Overs, {Bronwyn J.} and {Paill{\`e}re Martinot}, Marie-laure and Ronny Redlich and Marques, {Tiago Reis} and Jonathan Repple and Gloria Roberts and Roshchupkin, {Gennady V.} and Nikita Setiaman and Elena Shumskaya and Frederike Stein and Gustavo Sudre and Shun Takahashi and Anbupalam Thalamuthu and Diana Tordesillas-guti{\'e}rrez and {Van Der Lugt}, Aad and {Van Haren}, {Neeltje E. M.} and Wardlaw, {Joanna M.} and Wei Wen and Henk-jan Westeneng and Katharina Wittfeld and Zhu, {Alyssa H.} and Andre Zugman and Armstrong, {Nicola J.} and Gaia Bonfiglio and Janita Bralten and Shareefa Dalvie and Gail Davies and {Di Forti}, Marta and Linda Ding and Gary Donohoe and Forstner, {Andreas J.} and Javier Gonzalez-pe{\~n}as and Guimaraes, {Joao P. O. F. T.} and Georg Homuth and Jouke-jan Hottenga and Knol, {Maria J.} and Kwok, {John B. J.} and {Le Hellard}, Stephanie and Mather, {Karen A.} and Yuri Milaneschi and Morris, {Derek W.} and N{\"o}then, {Markus M.} and Sergi Papiol and Marcella Rietschel and Santoro, {Marcos L.} and Steen, {Vidar M.} and Stein, {Jason L.} and Fabian Streit and Tankard, {Rick M.} and Alexander Teumer and {Van {\textquoteleft}t Ent}, Dennis and {Van Der Meer}, Dennis and {Van Eijk}, {Kristel R.} and Evangelos Vassos and Javier V{\'a}zquez-bourgon and Witt, {Stephanie H.} and R{\"u}diger Br{\"u}hl and {Papadopoulos Orfanos}, Dimitri and Tom{\'a}{\v s} Paus and Sabina Millenet and Adams, {Hieab H. H.} and Ingrid Agartz and David Ames and Katrin Amunts and Andreassen, {Ole A.} and Celso Arango and Tobias Banaschewski and Baune, {Bernhard T.} and Belangero, {Sintia I.} and Bokde, {Arun L. W.} and Boomsma, {Dorret I.} and Bressan, {Rodrigo A.} and Henry Brodaty and Buitelaar, {Jan K.} and Wiepke Cahn and Svenja Caspers and Sven Cichon and Benedicto Crespo-facorro and Cox, {Simon R.} and Udo Dannlowski and Torbj{\o}rn Elvs{\aa}shagen and Thomas Espeseth and Falkai, {Peter G.} and Fisher, {Simon E.} and Herta Flor and Fullerton, {Janice M.} and Hugh Garavan and Gowland, {Penny A.} and Grabe, {Hans J.} and Tim Hahn and Andreas Heinz and Manon Hillegers and Jacqueline Hoare and Hoekstra, {Pieter J.} and Ikram, {Mohammad A.} and Jackowski, {Andrea P.} and Andreas Jansen and J{\"o}nsson, {Erik G.} and Kahn, {Rene S.} and Tilo Kircher and Korgaonkar, {Mayuresh S.} and Axel Krug and Herve Lemaitre and Malt, {Ulrik F.} and Jean-luc Martinot and Colm Mcdonald and Mitchell, {Philip B.} and Muetzel, {Ryan L.} and Murray, {Robin M.} and Frauke Nees and Igor Nenadi{\'c} and Jaap Oosterlaan and Ophoff, {Roel A.} and Pan, {Pedro M.} and Penninx, {Brenda W. J. H.} and Luise Poustka and Sachdev, {Perminder S.} and Salum, {Giovanni A.} and Schofield, {Peter R.} and Gunter Schumann and Philip Shaw and Kang Sim and Smolka, {Michael N.} and Stein, {Dan J.} and Trollor, {Julian N.} and {Van Den Berg}, {Leonard H.} and Veldink, {Jan H.} and Henrik Walter and Westlye, {Lars T.} and Robert Whelan and Tonya White and Wright, {Margaret J.} and Medland, {Sarah E.} and Barbara Franke and Thompson, {Paul M.} and {Hulshoff Pol}, {Hilleke E.}",

note = "Funding Information: B.F. has received speaking fees from MEDICE Arzneimittel P{\"u}tter GmbH & Co. B.W.J.H.P. has received research funding from Jansen Research and Boehringer Ingelheim. C.A. has been a consultant to or has received honoraria or grants from Acadia, Angelini, Gedeon Richter, Janssen Cilag, Lundbeck, Minerva, Otsuka, Roche, Sage, Servier, Shire, Schering Plough, Sumitomo Dainippon Pharma, Sunovion and Takeda. C.D.W. is an employee of Biogen, Inc. D.J.S. has received research grants and/or consultancy honoraria from Lundbeck and Sun. G.J.B. receives honoraria for teaching from GE Healthcare. H.B. is on the Advisory Board Nutricia Australia. H.E.H. has received travel fees for membership of the Steering Committee of the Lundbeck Foundation Center for Clinical Intervention and Neuropsychiatric Schizophrenia Research and for two presentations from Philips. These concerned activities were unrelated to the submitted work. H.J.G. has received travel grants and speaker{\textquoteright}s honoraria from Fresenius Medical Care, Neuraxpharm, Servier and Janssen Cilag as well as research funding from Fresenius Medical Care. L.P. has served as an advisor or consultant to Shire, Takeda and Roche. L.P. has also received speaking fees from Shire and Infectopharm. The present work is unrelated to these relationships. M.H.J. received grant support from the Brain and Behavior Foundation (NARSAD) Independent Investigator grant 20244. M.M.N. has received fees for memberships in Scientific Advisory Boards from the Lundbeck Foundation and Robert Bosch Stiftung and for membership in the Medical-Scientific Editorial Office of the Deutsches {\"A}rzteblatt. M.M.N. was reimbursed travel expenses for a conference participation by Shire Deutschland GmbH. M.M.N. receives salary payments from Life & Brain GmbH and holds shares in Life & Brain GmbH. All these concerned activities are outside the submitted work. N.J. and P.M.T. are multiple principal investigators of a research grant from Biogen, Inc for work unrelated to the contents of this manuscript. O.A.A. has received speaker{\textquoteright}s honoraria from Lundbeck and has been a consultant for HealthLytix. P.S.S. reports on/off payment for an advisory board meeting of Biogen. T.B. served in an advisory or consultancy role for Lundbeck, Medice, Neurim Pharmaceuticals, Oberberg GmbH, Shire and Infectopharm. T.B. also received conference support or speaker{\textquoteright}s fees from Lilly, Medice and Shire and received royalties from Hogrefe, Kohlhammer, CIP Medien and Oxford University Press. The present work is unrelated to these relationships. T.E.l. has received speaker{\textquoteright}s fees from Lundbeck. T.R.M. has received honoraria for speaking and chairing engagements from Lundbeck, Janssen and Astellas. Other authors declare no conflicts of interest. Publisher Copyright: {\textcopyright} 2022, The Author(s), under exclusive licence to Springer Nature America, Inc.",

year = "2022",

month = apr,

day = "5",

doi = "10.1038/s41593-022-01042-4",

language = "English",

volume = "25",

pages = "421--432",

journal = "Nature Neuroscience",

issn = "1097-6256",

publisher = "Nature Publishing Group",

number = "4",

}

TY - JOUR

T1 - Genetic variants associated with longitudinal changes in brain structure across the lifespan

AU - IMAGEN Consortium

AU - Brouwer, Rachel M.

AU - Klein, Marieke

AU - Grasby, Katrina L.

AU - Schnack, Hugo G.

AU - Jahanshad, Neda

AU - Teeuw, Jalmar

AU - Thomopoulos, Sophia I.

AU - Sprooten, Emma

AU - Franz, Carol E.

AU - Gogtay, Nitin

AU - Kremen, William S.

AU - Panizzon, Matthew S.

AU - Olde Loohuis, Loes M.

AU - Whelan, Christopher D.

AU - Aghajani, Moji

AU - Alloza, Clara

AU - Alnæs, Dag

AU - Artiges, Eric

AU - Ayesa-arriola, Rosa

AU - Barker, Gareth J.

AU - Bastin, Mark E.

AU - Blok, Elisabet

AU - Bøen, Erlend

AU - Breukelaar, Isabella A.

AU - Bright, Joanna K.

AU - Buimer, Elizabeth E. L.

AU - Bülow, Robin

AU - Cannon, Dara M.

AU - Ciufolini, Simone

AU - Crossley, Nicolas A.

AU - Damatac, Christienne G.

AU - Dazzan, Paola

AU - De Mol, Casper L.

AU - De Zwarte, Sonja M. C.

AU - Desrivières, Sylvane

AU - Díaz-caneja, Covadonga M.

AU - Doan, Nhat Trung

AU - Dohm, Katharina

AU - Fröhner, Juliane H.

AU - Goltermann, Janik

AU - Grigis, Antoine

AU - Grotegerd, Dominik

AU - Han, Laura K. M.

AU - Harris, Mathew A.

AU - Hartman, Catharina A.

AU - Heany, Sarah J.

AU - Heindel, Walter

AU - Heslenfeld, Dirk J.

AU - Hohmann, Sarah

AU - Ittermann, Bernd

AU - Jansen, Philip R.

AU - Janssen, Joost

AU - Jia, Tianye

AU - Jiang, Jiyang

AU - Jockwitz, Christiane

AU - Karali, Temmuz

AU - Keeser, Daniel

AU - Koevoets, Martijn G. J. C.

AU - Lenroot, Rhoshel K.

AU - Malchow, Berend

AU - Mandl, René C. W.

AU - Medel, Vicente

AU - Meinert, Susanne

AU - Morgan, Catherine A.

AU - Mühleisen, Thomas W.

AU - Nabulsi, Leila

AU - Opel, Nils

AU - De La Foz, Víctor Ortiz-garcía

AU - Overs, Bronwyn J.

AU - Paillère Martinot, Marie-laure

AU - Redlich, Ronny

AU - Marques, Tiago Reis

AU - Repple, Jonathan

AU - Roberts, Gloria

AU - Roshchupkin, Gennady V.

AU - Setiaman, Nikita

AU - Shumskaya, Elena

AU - Stein, Frederike

AU - Sudre, Gustavo

AU - Takahashi, Shun

AU - Thalamuthu, Anbupalam

AU - Tordesillas-gutiérrez, Diana

AU - Van Der Lugt, Aad

AU - Van Haren, Neeltje E. M.

AU - Wardlaw, Joanna M.

AU - Wen, Wei

AU - Westeneng, Henk-jan

AU - Wittfeld, Katharina

AU - Zhu, Alyssa H.

AU - Zugman, Andre

AU - Armstrong, Nicola J.

AU - Bonfiglio, Gaia

AU - Bralten, Janita

AU - Dalvie, Shareefa

AU - Davies, Gail

AU - Di Forti, Marta

AU - Ding, Linda

AU - Donohoe, Gary

AU - Forstner, Andreas J.

AU - Gonzalez-peñas, Javier

AU - Guimaraes, Joao P. O. F. T.

AU - Homuth, Georg

AU - Hottenga, Jouke-jan

AU - Knol, Maria J.

AU - Kwok, John B. J.

AU - Le Hellard, Stephanie

AU - Mather, Karen A.

AU - Milaneschi, Yuri

AU - Morris, Derek W.

AU - Nöthen, Markus M.

AU - Papiol, Sergi

AU - Rietschel, Marcella

AU - Santoro, Marcos L.

AU - Steen, Vidar M.

AU - Stein, Jason L.

AU - Streit, Fabian

AU - Tankard, Rick M.

AU - Teumer, Alexander

AU - Van ‘t Ent, Dennis

AU - Van Der Meer, Dennis

AU - Van Eijk, Kristel R.

AU - Vassos, Evangelos

AU - Vázquez-bourgon, Javier

AU - Witt, Stephanie H.

AU - Brühl, Rüdiger

AU - Papadopoulos Orfanos, Dimitri

AU - Paus, Tomáš

AU - Millenet, Sabina

AU - Adams, Hieab H. H.

AU - Agartz, Ingrid

AU - Ames, David

AU - Amunts, Katrin

AU - Andreassen, Ole A.

AU - Arango, Celso

AU - Banaschewski, Tobias

AU - Baune, Bernhard T.

AU - Belangero, Sintia I.

AU - Bokde, Arun L. W.

AU - Boomsma, Dorret I.

AU - Bressan, Rodrigo A.

AU - Brodaty, Henry

AU - Buitelaar, Jan K.

AU - Cahn, Wiepke

AU - Caspers, Svenja

AU - Cichon, Sven

AU - Crespo-facorro, Benedicto

AU - Cox, Simon R.

AU - Dannlowski, Udo

AU - Elvsåshagen, Torbjørn

AU - Espeseth, Thomas

AU - Falkai, Peter G.

AU - Fisher, Simon E.

AU - Flor, Herta

AU - Fullerton, Janice M.

AU - Garavan, Hugh

AU - Gowland, Penny A.

AU - Grabe, Hans J.

AU - Hahn, Tim

AU - Heinz, Andreas

AU - Hillegers, Manon

AU - Hoare, Jacqueline

AU - Hoekstra, Pieter J.

AU - Ikram, Mohammad A.

AU - Jackowski, Andrea P.

AU - Jansen, Andreas

AU - Jönsson, Erik G.

AU - Kahn, Rene S.

AU - Kircher, Tilo

AU - Korgaonkar, Mayuresh S.

AU - Krug, Axel

AU - Lemaitre, Herve

AU - Malt, Ulrik F.

AU - Martinot, Jean-luc

AU - Mcdonald, Colm

AU - Mitchell, Philip B.

AU - Muetzel, Ryan L.

AU - Murray, Robin M.

AU - Nees, Frauke

AU - Nenadić, Igor

AU - Oosterlaan, Jaap

AU - Ophoff, Roel A.

AU - Pan, Pedro M.

AU - Penninx, Brenda W. J. H.

AU - Poustka, Luise

AU - Sachdev, Perminder S.

AU - Salum, Giovanni A.

AU - Schofield, Peter R.

AU - Schumann, Gunter

AU - Shaw, Philip

AU - Sim, Kang

AU - Smolka, Michael N.

AU - Stein, Dan J.

AU - Trollor, Julian N.

AU - Van Den Berg, Leonard H.

AU - Veldink, Jan H.

AU - Walter, Henrik

AU - Westlye, Lars T.

AU - Whelan, Robert

AU - White, Tonya

AU - Wright, Margaret J.

AU - Medland, Sarah E.

AU - Franke, Barbara

AU - Thompson, Paul M.

AU - Hulshoff Pol, Hilleke E.

N1 - Funding Information: B.F. has received speaking fees from MEDICE Arzneimittel Pütter GmbH & Co. B.W.J.H.P. has received research funding from Jansen Research and Boehringer Ingelheim. C.A. has been a consultant to or has received honoraria or grants from Acadia, Angelini, Gedeon Richter, Janssen Cilag, Lundbeck, Minerva, Otsuka, Roche, Sage, Servier, Shire, Schering Plough, Sumitomo Dainippon Pharma, Sunovion and Takeda. C.D.W. is an employee of Biogen, Inc. D.J.S. has received research grants and/or consultancy honoraria from Lundbeck and Sun. G.J.B. receives honoraria for teaching from GE Healthcare. H.B. is on the Advisory Board Nutricia Australia. H.E.H. has received travel fees for membership of the Steering Committee of the Lundbeck Foundation Center for Clinical Intervention and Neuropsychiatric Schizophrenia Research and for two presentations from Philips. These concerned activities were unrelated to the submitted work. H.J.G. has received travel grants and speaker’s honoraria from Fresenius Medical Care, Neuraxpharm, Servier and Janssen Cilag as well as research funding from Fresenius Medical Care. L.P. has served as an advisor or consultant to Shire, Takeda and Roche. L.P. has also received speaking fees from Shire and Infectopharm. The present work is unrelated to these relationships. M.H.J. received grant support from the Brain and Behavior Foundation (NARSAD) Independent Investigator grant 20244. M.M.N. has received fees for memberships in Scientific Advisory Boards from the Lundbeck Foundation and Robert Bosch Stiftung and for membership in the Medical-Scientific Editorial Office of the Deutsches Ärzteblatt. M.M.N. was reimbursed travel expenses for a conference participation by Shire Deutschland GmbH. M.M.N. receives salary payments from Life & Brain GmbH and holds shares in Life & Brain GmbH. All these concerned activities are outside the submitted work. N.J. and P.M.T. are multiple principal investigators of a research grant from Biogen, Inc for work unrelated to the contents of this manuscript. O.A.A. has received speaker’s honoraria from Lundbeck and has been a consultant for HealthLytix. P.S.S. reports on/off payment for an advisory board meeting of Biogen. T.B. served in an advisory or consultancy role for Lundbeck, Medice, Neurim Pharmaceuticals, Oberberg GmbH, Shire and Infectopharm. T.B. also received conference support or speaker’s fees from Lilly, Medice and Shire and received royalties from Hogrefe, Kohlhammer, CIP Medien and Oxford University Press. The present work is unrelated to these relationships. T.E.l. has received speaker’s fees from Lundbeck. T.R.M. has received honoraria for speaking and chairing engagements from Lundbeck, Janssen and Astellas. Other authors declare no conflicts of interest. Publisher Copyright: © 2022, The Author(s), under exclusive licence to Springer Nature America, Inc.

PY - 2022/4/5

Y1 - 2022/4/5

U2 - 10.1038/s41593-022-01042-4

DO - 10.1038/s41593-022-01042-4

M3 - Article

VL - 25

SP - 421

EP - 432

JO - Nature Neuroscience

JF - Nature Neuroscience

SN - 1097-6256

IS - 4

ER -