Genetic variation in complement regulators and susceptibility to age-related macular degeneration

Valentina Cipriani, Baljinder K Matharu, Jane C Khan, Humma Shahid, Chloe M Stanton, Caroline Hayward, Alan F Wright, Catey Bunce, David G Clayton, Anthony T Moore, John R W Yates

Research output: Contribution to journalArticlepeer-review

Abstract

Age-related macular degeneration (AMD) is the commonest cause of blindness in Western populations. Risk is influenced by age, genetic and environmental factors. Complement activation appears to be important in the pathogenesis and associations have been found between AMD and genetic variations in complement regulators such as complement factor H. We therefore investigated other complement regulators for association with AMD.
Original languageEnglish
Pages (from-to)158-61
Number of pages4
JournalImmunobiology
Volume217
Issue number2
DOIs
Publication statusPublished - 2012

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