Genetic variation in Hyperpolarization-activated cyclic nucleotide-gated channels and its relationship with neuroticism, cognition and risk of depression

Andrew M McIntosh; Arthur A Simen; Kathryn L Evans; Jeremy Hall; Donald J MacIntyre; Douglas Blackwood; Andrew Morris; Blair H Smith; Anna Dominiczak; David Porteous; Ian Deary; Pippa A Thomson

doi:10.3389/fgene.2012.00116

Genetic variation in Hyperpolarization-activated cyclic nucleotide-gated channels and its relationship with neuroticism, cognition and risk of depression

Andrew M McIntosh, Arthur A Simen, Kathryn L Evans, Jeremy Hall, Donald J MacIntyre, Douglas Blackwood, Andrew Morris, Blair H Smith, Anna Dominiczak, David Porteous, Ian Deary, Pippa A Thomson

Research output: Contribution to journal › Article › peer-review

Abstract / Description of output

Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels are encoded by four genes (HCN1-4) and, through activation by cyclic AMP (cAMP), represent a point of convergence for several psychosis risk genes. On the basis of positive preliminary data, we sought to test whether genetic variation in HCN1-4 conferred risk of depression or cognitive impairment in the Generation Scotland: Scottish Family Health Study. HCN1, HCN2, HCN3, and HCN4 were genotyped for 43 haplotype-tagging SNPs and tested for association with DSM-IV depression, neuroticism, and a battery of cognitive tests assessing cognitive ability, memory, verbal fluency, and psychomotor performance. No association was found between any HCN channel gene SNP and risk of depression, neuroticism, or on any cognitive measure. The current study does not support a genetic role for HCN channels in conferring risk of depression or cognitive impairment in individuals from the Scottish population.

Original language	English
Pages (from-to)	116
Journal	Frontiers in Genetics
Volume	3
DOIs	https://doi.org/10.3389/fgene.2012.00116
Publication status	Published - 2012

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10.3389/fgene.2012.00116

Genetic variation in Hyperpolarization-activated cyclic nucleotide-gated channels and its relationship with neuroticism, cognition and risk of depression
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http://www.frontiersin.org/Behavioral_and_Psychiatric_Genetics/10.3389/fgene.2012.00116/abstract

Genetic Variation in HCN1-4 and it's relationship to cognition and depression in individuals from the Generation Scotland: Scotrish Family Health Study
McIntosh, A., Deary, I., Evans, K., Hall, J. & Thomson, P.
UK central government bodies/local authorities, health and hospital authorities
1/01/11 → 31/03/12
Project: Research

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McIntosh, A. M., Simen, A. A., Evans, K. L., Hall, J., MacIntyre, D. J., Blackwood, D., Morris, A., Smith, B. H., Dominiczak, A., Porteous, D., Deary, I., & Thomson, P. A. (2012). Genetic variation in Hyperpolarization-activated cyclic nucleotide-gated channels and its relationship with neuroticism, cognition and risk of depression. Frontiers in Genetics, 3, 116. https://doi.org/10.3389/fgene.2012.00116

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title = "Genetic variation in Hyperpolarization-activated cyclic nucleotide-gated channels and its relationship with neuroticism, cognition and risk of depression",

abstract = "Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels are encoded by four genes (HCN1-4) and, through activation by cyclic AMP (cAMP), represent a point of convergence for several psychosis risk genes. On the basis of positive preliminary data, we sought to test whether genetic variation in HCN1-4 conferred risk of depression or cognitive impairment in the Generation Scotland: Scottish Family Health Study. HCN1, HCN2, HCN3, and HCN4 were genotyped for 43 haplotype-tagging SNPs and tested for association with DSM-IV depression, neuroticism, and a battery of cognitive tests assessing cognitive ability, memory, verbal fluency, and psychomotor performance. No association was found between any HCN channel gene SNP and risk of depression, neuroticism, or on any cognitive measure. The current study does not support a genetic role for HCN channels in conferring risk of depression or cognitive impairment in individuals from the Scottish population.",

author = "McIntosh, {Andrew M} and Simen, {Arthur A} and Evans, {Kathryn L} and Jeremy Hall and MacIntyre, {Donald J} and Douglas Blackwood and Andrew Morris and Smith, {Blair H} and Anna Dominiczak and David Porteous and Ian Deary and Thomson, {Pippa A}",

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McIntosh, AM, Simen, AA, Evans, KL, Hall, J, MacIntyre, DJ, Blackwood, D, Morris, A, Smith, BH, Dominiczak, A, Porteous, D, Deary, I & Thomson, PA 2012, 'Genetic variation in Hyperpolarization-activated cyclic nucleotide-gated channels and its relationship with neuroticism, cognition and risk of depression', Frontiers in Genetics, vol. 3, pp. 116. https://doi.org/10.3389/fgene.2012.00116

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AU - McIntosh, Andrew M

AU - Simen, Arthur A

AU - Evans, Kathryn L

AU - Hall, Jeremy

AU - MacIntyre, Donald J

AU - Blackwood, Douglas

AU - Morris, Andrew

AU - Smith, Blair H

AU - Dominiczak, Anna

AU - Porteous, David

AU - Deary, Ian

AU - Thomson, Pippa A

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AB - Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels are encoded by four genes (HCN1-4) and, through activation by cyclic AMP (cAMP), represent a point of convergence for several psychosis risk genes. On the basis of positive preliminary data, we sought to test whether genetic variation in HCN1-4 conferred risk of depression or cognitive impairment in the Generation Scotland: Scottish Family Health Study. HCN1, HCN2, HCN3, and HCN4 were genotyped for 43 haplotype-tagging SNPs and tested for association with DSM-IV depression, neuroticism, and a battery of cognitive tests assessing cognitive ability, memory, verbal fluency, and psychomotor performance. No association was found between any HCN channel gene SNP and risk of depression, neuroticism, or on any cognitive measure. The current study does not support a genetic role for HCN channels in conferring risk of depression or cognitive impairment in individuals from the Scottish population.

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DO - 10.3389/fgene.2012.00116

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SN - 1664-8021

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SP - 116

JO - Frontiers in Genetics

JF - Frontiers in Genetics

ER -

Genetic variation in Hyperpolarization-activated cyclic nucleotide-gated channels and its relationship with neuroticism, cognition and risk of depression

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Genetic Variation in HCN1-4 and it's relationship to cognition and depression in individuals from the Generation Scotland: Scotrish Family Health Study

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