Genetic variation in the familial Mediterranean fever gene (MEFV) and risk for Crohn's disease and ulcerative colitis

Alexandra-Chloé Villani; Mathieu Lemire; Edouard Louis; Mark S Silverberg; Catherine Collette; Geneviève Fortin; Elaine R Nimmo; Yannick Renaud; Sébastien Brunet; Cécile Libioulle; Jacques Belaiche; Alain Bitton; Daniel Gaudet; Albert Cohen; Diane Langelier; John D Rioux; Ian D R Arnott; Gary E Wild; Paul Rutgeerts; Jack Satsangi; Séverine Vermeire; Thomas J Hudson; Denis Franchimont

doi:10.1371/journal.pone.0007154

Genetic variation in the familial Mediterranean fever gene (MEFV) and risk for Crohn's disease and ulcerative colitis

Alexandra-Chloé Villani, Mathieu Lemire, Edouard Louis, Mark S Silverberg, Catherine Collette, Geneviève Fortin, Elaine R Nimmo, Yannick Renaud, Sébastien Brunet, Cécile Libioulle, Jacques Belaiche, Alain Bitton, Daniel Gaudet, Albert Cohen, Diane Langelier, John D Rioux, Ian D R Arnott, Gary E Wild, Paul Rutgeerts, Jack SatsangiSéverine Vermeire, Thomas J Hudson, Denis Franchimont

Research output: Contribution to journal › Article › peer-review

Abstract

The familial Mediterranean fever (FMF) gene (MEFV) encodes pyrin, a major regulator of the inflammasome platform controlling caspase-1 activation and IL-1beta processing. Pyrin has been shown to interact with the gene product of NLRP3, NALP3/cryopyrin, also an important active member of the inflammasome. The NLRP3 region was recently reported to be associated with Crohn's disease (CD) susceptibility. We therefore sought to evaluate MEFV as an inflammatory bowel disease (IBD) susceptibility gene.

Original language	English
Pages (from-to)	e7154
Journal	PLoS ONE
Volume	4
Issue number	9
DOIs	https://doi.org/10.1371/journal.pone.0007154
Publication status	Published - 2009

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10.1371/journal.pone.0007154

Genetic variation in the familial Mediterranean fever gene (MEFV) and risk for Crohn's disease and ulcerative colitis
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http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0007154

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Villani, A.-C., Lemire, M., Louis, E., Silverberg, M. S., Collette, C., Fortin, G., Nimmo, E. R., Renaud, Y., Brunet, S., Libioulle, C., Belaiche, J., Bitton, A., Gaudet, D., Cohen, A., Langelier, D., Rioux, J. D., Arnott, I. D. R., Wild, G. E., Rutgeerts, P., ... Franchimont, D. (2009). Genetic variation in the familial Mediterranean fever gene (MEFV) and risk for Crohn's disease and ulcerative colitis. PLoS ONE, 4(9), e7154. https://doi.org/10.1371/journal.pone.0007154

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title = "Genetic variation in the familial Mediterranean fever gene (MEFV) and risk for Crohn's disease and ulcerative colitis",

abstract = "The familial Mediterranean fever (FMF) gene (MEFV) encodes pyrin, a major regulator of the inflammasome platform controlling caspase-1 activation and IL-1beta processing. Pyrin has been shown to interact with the gene product of NLRP3, NALP3/cryopyrin, also an important active member of the inflammasome. The NLRP3 region was recently reported to be associated with Crohn's disease (CD) susceptibility. We therefore sought to evaluate MEFV as an inflammatory bowel disease (IBD) susceptibility gene.",

author = "Alexandra-Chlo{\'e} Villani and Mathieu Lemire and Edouard Louis and Silverberg, {Mark S} and Catherine Collette and Genevi{\`e}ve Fortin and Nimmo, {Elaine R} and Yannick Renaud and S{\'e}bastien Brunet and C{\'e}cile Libioulle and Jacques Belaiche and Alain Bitton and Daniel Gaudet and Albert Cohen and Diane Langelier and Rioux, {John D} and Arnott, {Ian D R} and Wild, {Gary E} and Paul Rutgeerts and Jack Satsangi and S{\'e}verine Vermeire and Hudson, {Thomas J} and Denis Franchimont",

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Villani, A-C, Lemire, M, Louis, E, Silverberg, MS, Collette, C, Fortin, G, Nimmo, ER, Renaud, Y, Brunet, S, Libioulle, C, Belaiche, J, Bitton, A, Gaudet, D, Cohen, A, Langelier, D, Rioux, JD, Arnott, IDR, Wild, GE, Rutgeerts, P, Satsangi, J, Vermeire, S, Hudson, TJ & Franchimont, D 2009, 'Genetic variation in the familial Mediterranean fever gene (MEFV) and risk for Crohn's disease and ulcerative colitis', PLoS ONE, vol. 4, no. 9, pp. e7154. https://doi.org/10.1371/journal.pone.0007154

TY - JOUR

T1 - Genetic variation in the familial Mediterranean fever gene (MEFV) and risk for Crohn's disease and ulcerative colitis

AU - Villani, Alexandra-Chloé

AU - Lemire, Mathieu

AU - Louis, Edouard

AU - Silverberg, Mark S

AU - Collette, Catherine

AU - Fortin, Geneviève

AU - Nimmo, Elaine R

AU - Renaud, Yannick

AU - Brunet, Sébastien

AU - Libioulle, Cécile

AU - Belaiche, Jacques

AU - Bitton, Alain

AU - Gaudet, Daniel

AU - Cohen, Albert

AU - Langelier, Diane

AU - Rioux, John D

AU - Arnott, Ian D R

AU - Wild, Gary E

AU - Rutgeerts, Paul

AU - Satsangi, Jack

AU - Vermeire, Séverine

AU - Hudson, Thomas J

AU - Franchimont, Denis

PY - 2009

Y1 - 2009

N2 - The familial Mediterranean fever (FMF) gene (MEFV) encodes pyrin, a major regulator of the inflammasome platform controlling caspase-1 activation and IL-1beta processing. Pyrin has been shown to interact with the gene product of NLRP3, NALP3/cryopyrin, also an important active member of the inflammasome. The NLRP3 region was recently reported to be associated with Crohn's disease (CD) susceptibility. We therefore sought to evaluate MEFV as an inflammatory bowel disease (IBD) susceptibility gene.

AB - The familial Mediterranean fever (FMF) gene (MEFV) encodes pyrin, a major regulator of the inflammasome platform controlling caspase-1 activation and IL-1beta processing. Pyrin has been shown to interact with the gene product of NLRP3, NALP3/cryopyrin, also an important active member of the inflammasome. The NLRP3 region was recently reported to be associated with Crohn's disease (CD) susceptibility. We therefore sought to evaluate MEFV as an inflammatory bowel disease (IBD) susceptibility gene.

U2 - 10.1371/journal.pone.0007154

DO - 10.1371/journal.pone.0007154

M3 - Article

C2 - 19784369

SN - 1932-6203

VL - 4

SP - e7154

JO - PLoS ONE

JF - PLoS ONE

IS - 9

ER -

Genetic variation in the familial Mediterranean fever gene (MEFV) and risk for Crohn's disease and ulcerative colitis

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