Genetic variation of the APOE promoter and outcome after head injury

CL Lendon*, JM Harris, AL Pritchard, JAR Nicoll, GM Teasdale, G Murray

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

The APOE-epsilon4 allele is associated with risk for Alzheimer's disease (AD) and poorer outcome after head injury. Several studies show that polymorphisms in the promoter that influence APOE expression also increase risk for AD. The authors' data from a study of 92 patients are consistent with a possible influence of the G-219T promoter polymorphism on outcome after head injury. The group with unfavorable outcome had a genotype frequency distribution similar to that found in AD.

Original languageEnglish
Pages (from-to)683-685
Number of pages3
JournalNeurology
Volume61
Issue number5
Publication statusPublished - 9 Sep 2003

Keywords

  • TRAUMATIC BRAIN INJURY
  • APOLIPOPROTEIN-E GENE
  • ALZHEIMERS-DISEASE
  • POLYMORPHISMS

Fingerprint

Dive into the research topics of 'Genetic variation of the APOE promoter and outcome after head injury'. Together they form a unique fingerprint.

Cite this