Genetic variation of the APOE promoter and outcome after head injury

CL Lendon; JM Harris; AL Pritchard; JAR Nicoll; GM Teasdale; G Murray

Genetic variation of the APOE promoter and outcome after head injury

CL Lendon^*, JM Harris, AL Pritchard, JAR Nicoll, GM Teasdale, G Murray

^*Corresponding author for this work

Deanery of Molecular, Genetic and Population Health Sciences

Research output: Contribution to journal › Article › peer-review

Abstract / Description of output

The APOE-epsilon4 allele is associated with risk for Alzheimer's disease (AD) and poorer outcome after head injury. Several studies show that polymorphisms in the promoter that influence APOE expression also increase risk for AD. The authors' data from a study of 92 patients are consistent with a possible influence of the G-219T promoter polymorphism on outcome after head injury. The group with unfavorable outcome had a genotype frequency distribution similar to that found in AD.

Original language	English
Pages (from-to)	683-685
Number of pages	3
Journal	Neurology
Volume	61
Issue number	5
Publication status	Published - 9 Sept 2003

Keywords / Materials (for Non-textual outputs)

TRAUMATIC BRAIN INJURY
APOLIPOPROTEIN-E GENE
ALZHEIMERS-DISEASE
POLYMORPHISMS

Cite this

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title = "Genetic variation of the APOE promoter and outcome after head injury",

abstract = "The APOE-epsilon4 allele is associated with risk for Alzheimer's disease (AD) and poorer outcome after head injury. Several studies show that polymorphisms in the promoter that influence APOE expression also increase risk for AD. The authors' data from a study of 92 patients are consistent with a possible influence of the G-219T promoter polymorphism on outcome after head injury. The group with unfavorable outcome had a genotype frequency distribution similar to that found in AD.",

keywords = "TRAUMATIC BRAIN INJURY, APOLIPOPROTEIN-E GENE, ALZHEIMERS-DISEASE, POLYMORPHISMS",

author = "CL Lendon and JM Harris and AL Pritchard and JAR Nicoll and GM Teasdale and G Murray",

year = "2003",

month = sep,

day = "9",

language = "English",

volume = "61",

pages = "683--685",

journal = "Neurology",

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publisher = "Lippincott Williams and Wilkins",

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TY - JOUR

T1 - Genetic variation of the APOE promoter and outcome after head injury

AU - Lendon, CL

AU - Harris, JM

AU - Pritchard, AL

AU - Nicoll, JAR

AU - Teasdale, GM

AU - Murray, G

PY - 2003/9/9

Y1 - 2003/9/9

N2 - The APOE-epsilon4 allele is associated with risk for Alzheimer's disease (AD) and poorer outcome after head injury. Several studies show that polymorphisms in the promoter that influence APOE expression also increase risk for AD. The authors' data from a study of 92 patients are consistent with a possible influence of the G-219T promoter polymorphism on outcome after head injury. The group with unfavorable outcome had a genotype frequency distribution similar to that found in AD.

AB - The APOE-epsilon4 allele is associated with risk for Alzheimer's disease (AD) and poorer outcome after head injury. Several studies show that polymorphisms in the promoter that influence APOE expression also increase risk for AD. The authors' data from a study of 92 patients are consistent with a possible influence of the G-219T promoter polymorphism on outcome after head injury. The group with unfavorable outcome had a genotype frequency distribution similar to that found in AD.

KW - TRAUMATIC BRAIN INJURY

KW - APOLIPOPROTEIN-E GENE

KW - ALZHEIMERS-DISEASE

KW - POLYMORPHISMS

M3 - Article

SN - 0028-3878

VL - 61

SP - 683

EP - 685

JO - Neurology

JF - Neurology

IS - 5

ER -

Genetic variation of the APOE promoter and outcome after head injury

Abstract / Description of output

Keywords / Materials (for Non-textual outputs)

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