Genetic variation within the Y chromosome is not associated with histological characteristics of the atherosclerotic carotid artery or aneurysmal wall

Saskia Haitjema, Jessica Van Setten, James Eales, Sander W. Van Der Laan, Ilaria Gandin, Jean-paul P.m. De Vries, Gert J. De Borst, Gerard Pasterkamp, Folkert W. Asselbergs, Fadi J. Charchar, James F. Wilson, Saskia C.a. De Jager, Maciej Tomaszewski, Hester M. Den Ruijter

Research output: Contribution to journalArticlepeer-review

Abstract

Background and aims
Haplogroup I, a common European paternal lineage of the Y chromosome, is associated with increased risk of coronary artery disease in British men. It is unclear whether this haplogroup or any other haplogroup on the Y chromosome is associated with histological characteristics of the diseased vessel wall in other vascular manifestations of cardiovascular diseases showing a male preponderance.


Methods
We examined Dutch men undergoing either carotid endarterectomy from the Athero-Express biobank (AE, n = 1217) or open aneurysm repair from the Aneurysm-Express biobank (AAA, n = 393). Upon resolving the Y chromosome phylogeny, each man was assigned to one of the paternal lineages based on combinations of single nucleotide polymorphisms of the male-specific region of the Y chromosome. We examined the associations between the Y chromosome and the histological characteristics of the carotid plaque and aneurysm wall, including lipid content, leukocyte infiltration and intraplaque haemorrhage, in all men.


Results
A majority of men were carriers of either haplogroup I (AE: 28% AAA: 24%) or haplogroup R (AE: 59% AAA: 61%). We found no association between Y chromosomal haplogroups and histological characteristics of plaque collected from carotid arteries or tissue specimens of aneurysms. Moreover, the distribution of frequency for all Y chromosomal haplogroups in both cohorts was similar to that of a general population of Dutch men.



Conclusions
Our data show that genetic variation on the Y chromosome is not associated with histological characteristics of the plaques from carotid arteries or specimens of aneurysms in men of Dutch origin.
Original languageEnglish
JournalAtherosclerosis
Early online date20 Feb 2017
DOIs
Publication statusE-pub ahead of print - 20 Feb 2017

Keywords

  • Y Chromosome
  • Haplogroups
  • Plaque characteristics
  • Histology
  • MEN
  • Aneurysm
  • carotid endarterectomy

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