Genetical genomics of growth in a chicken model

Martin Johnsson; Rie Henriksen; Andrey Höglund; Jesper Fogelholm; Per Jensen; Dominic Wright

doi:10.1186/s12864-018-4441-3

Genetical genomics of growth in a chicken model

Martin Johnsson, Rie Henriksen, Andrey Höglund, Jesper Fogelholm, Per Jensen, Dominic Wright

Royal (Dick) School of Veterinary Studies

Research output: Contribution to journal › Article › peer-review

Abstract

The genetics underlying body mass and growth are key to understanding a wide range of topics in biology, both evolutionary and developmental. Body mass and growth traits are affected by many genetic variants of small effect. This complicates genetic mapping of growth and body mass. Experimental intercrosses between individuals from divergent populations allows us to map naturally occurring genetic variants for selected traits, such as body mass by linkage mapping. By simultaneously measuring traits and intermediary molecular phenotypes, such as gene expression, one can use integrative genomics to search for potential causative genes.

Original language	English
Pages (from-to)	72
Number of pages	1
Journal	BMC Genomics
Volume	19
Issue number	1
DOIs	https://doi.org/10.1186/s12864-018-4441-3
Publication status	Published - 23 Jan 2018

Keywords / Materials (for Non-textual outputs)

Growth
Liver
QTL
Gene expression
eQTL
Genetical genomics

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10.1186/s12864-018-4441-3

s12864-018-4441-3Final published version, 971 KBLicence: Creative Commons: Attribution (CC-BY)

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title = "Genetical genomics of growth in a chicken model",

abstract = "The genetics underlying body mass and growth are key to understanding a wide range of topics in biology, both evolutionary and developmental. Body mass and growth traits are affected by many genetic variants of small effect. This complicates genetic mapping of growth and body mass. Experimental intercrosses between individuals from divergent populations allows us to map naturally occurring genetic variants for selected traits, such as body mass by linkage mapping. By simultaneously measuring traits and intermediary molecular phenotypes, such as gene expression, one can use integrative genomics to search for potential causative genes.",

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T1 - Genetical genomics of growth in a chicken model

AU - Johnsson, Martin

AU - Henriksen, Rie

AU - Höglund, Andrey

AU - Fogelholm, Jesper

AU - Jensen, Per

AU - Wright, Dominic

PY - 2018/1/23

Y1 - 2018/1/23

N2 - The genetics underlying body mass and growth are key to understanding a wide range of topics in biology, both evolutionary and developmental. Body mass and growth traits are affected by many genetic variants of small effect. This complicates genetic mapping of growth and body mass. Experimental intercrosses between individuals from divergent populations allows us to map naturally occurring genetic variants for selected traits, such as body mass by linkage mapping. By simultaneously measuring traits and intermediary molecular phenotypes, such as gene expression, one can use integrative genomics to search for potential causative genes.

AB - The genetics underlying body mass and growth are key to understanding a wide range of topics in biology, both evolutionary and developmental. Body mass and growth traits are affected by many genetic variants of small effect. This complicates genetic mapping of growth and body mass. Experimental intercrosses between individuals from divergent populations allows us to map naturally occurring genetic variants for selected traits, such as body mass by linkage mapping. By simultaneously measuring traits and intermediary molecular phenotypes, such as gene expression, one can use integrative genomics to search for potential causative genes.

KW - Growth

KW - Liver

KW - QTL

KW - Gene expression

KW - eQTL

KW - Genetical genomics

U2 - 10.1186/s12864-018-4441-3

DO - 10.1186/s12864-018-4441-3

M3 - Article

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VL - 19

SP - 72

JO - BMC Genomics

JF - BMC Genomics

IS - 1

ER -

Genetical genomics of growth in a chicken model

Abstract

Keywords / Materials (for Non-textual outputs)

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