Genetics and Genomics of Social Behavior in a Chicken Model

Martin Johnsson; Rie Henriksen; Jesper Fogelholm; Andrey Höglund; Per Jensen; Dominic Wright

doi:10.1534/genetics.118.300810

Genetics and Genomics of Social Behavior in a Chicken Model

Martin Johnsson, Rie Henriksen, Jesper Fogelholm, Andrey Höglund, Per Jensen, Dominic Wright

Royal (Dick) School of Veterinary Studies

Research output: Contribution to journal › Article › peer-review

Abstract

The identification of genes affecting sociality can give insights into the maintenance and development of sociality and personality. In this study, we used the combination of an advanced intercross between wild and domestic chickens with a combined QTL and eQTL genetical genomics approach to identify genes for social reinstatement, a social and anxiety-related behavior. A total of 24 social reinstatement QTL were identified and overlaid with over 600 eQTL obtained from the same birds using hypothalamic tissue. Correlations between overlapping QTL and eQTL indicated 5 strong candidate genes, with the gene TTRAP being strongly significantly correlated with multiple aspects of social reinstatement behavior, as well as possessing a highly significant eQTL.

Original language	Undefined/Unknown
Pages (from-to)	209-221
Journal	Genetics
Volume	209
Issue number	1
Early online date	12 Mar 2018
DOIs	https://doi.org/10.1534/genetics.118.300810
Publication status	Published - May 2018

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10.1534/genetics.118.300810

http://www.genetics.org/content/early/2018/03/12/genetics.118.300810

Cite this

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title = "Genetics and Genomics of Social Behavior in a Chicken Model",

abstract = "The identification of genes affecting sociality can give insights into the maintenance and development of sociality and personality. In this study, we used the combination of an advanced intercross between wild and domestic chickens with a combined QTL and eQTL genetical genomics approach to identify genes for social reinstatement, a social and anxiety-related behavior. A total of 24 social reinstatement QTL were identified and overlaid with over 600 eQTL obtained from the same birds using hypothalamic tissue. Correlations between overlapping QTL and eQTL indicated 5 strong candidate genes, with the gene TTRAP being strongly significantly correlated with multiple aspects of social reinstatement behavior, as well as possessing a highly significant eQTL.",

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AU - Johnsson, Martin

AU - Henriksen, Rie

AU - Fogelholm, Jesper

AU - Höglund, Andrey

AU - Jensen, Per

AU - Wright, Dominic

PY - 2018/5

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AB - The identification of genes affecting sociality can give insights into the maintenance and development of sociality and personality. In this study, we used the combination of an advanced intercross between wild and domestic chickens with a combined QTL and eQTL genetical genomics approach to identify genes for social reinstatement, a social and anxiety-related behavior. A total of 24 social reinstatement QTL were identified and overlaid with over 600 eQTL obtained from the same birds using hypothalamic tissue. Correlations between overlapping QTL and eQTL indicated 5 strong candidate genes, with the gene TTRAP being strongly significantly correlated with multiple aspects of social reinstatement behavior, as well as possessing a highly significant eQTL.

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