Genetics of C-Peptide and Age at Diagnosis in Type 1 Diabetes

Delnaz Roshandel; Athina Spiliopoulou; Stuart J. McGurnaghan; Andrii Iakovliev; Debby Lipschutz; Caroline Hayward; Shelley B. Bull; Barbara E.K. Klein; Kristine E. Lee; Gregory L. Kinney; Marian Rewers; Tina Costacou; Rachel G. Miller; Paul M. McKeigue; Andrew D. Paterson; Helen M. Colhoun

doi:10.2337/db24-0340

Genetics of C-Peptide and Age at Diagnosis in Type 1 Diabetes

Delnaz Roshandel, Athina Spiliopoulou, Stuart J. McGurnaghan, Andrii Iakovliev, Debby Lipschutz, Caroline Hayward, Shelley B. Bull, Barbara E.K. Klein, Kristine E. Lee, Gregory L. Kinney, Marian Rewers, Tina Costacou, Rachel G. Miller, Paul M. McKeigue, Andrew D. Paterson^*, Helen M. Colhoun^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

ARTICLE HIGHLIGHTS: Identified genetic loci for C-peptide and type 1 diabetes (T1D) age at diagnosis (AAD) explain only a small proportion of their variation. We aimed to identify additional genetic loci associated with C-peptide and AAD. Some HLA allele/haplotypes associated with T1D also contributed to variability of C-peptide and AAD, whereas outside the HLA region, T1D loci were mostly not associated with C-peptide or AAD. Genetic variation within CTSH can affect AAD. There is still residual heritability of C-peptide and AAD outside of HLA that could benefit from larger meta-genome-wide association studies.

Original language	English
Pages (from-to)	223-233
Number of pages	11
Journal	Diabetes
Volume	74
Issue number	2
Early online date	18 Nov 2024
DOIs	https://doi.org/10.2337/db24-0340
Publication status	Published - 1 Feb 2025

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Roshandel, D., Spiliopoulou, A., McGurnaghan, S. J., Iakovliev, A., Lipschutz, D., Hayward, C., Bull, S. B., Klein, B. E. K., Lee, K. E., Kinney, G. L., Rewers, M., Costacou, T., Miller, R. G., McKeigue, P. M., Paterson, A. D., & Colhoun, H. M. (2025). Genetics of C-Peptide and Age at Diagnosis in Type 1 Diabetes. Diabetes , 74(2), 223-233. https://doi.org/10.2337/db24-0340

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abstract = "ARTICLE HIGHLIGHTS: Identified genetic loci for C-peptide and type 1 diabetes (T1D) age at diagnosis (AAD) explain only a small proportion of their variation. We aimed to identify additional genetic loci associated with C-peptide and AAD. Some HLA allele/haplotypes associated with T1D also contributed to variability of C-peptide and AAD, whereas outside the HLA region, T1D loci were mostly not associated with C-peptide or AAD. Genetic variation within CTSH can affect AAD. There is still residual heritability of C-peptide and AAD outside of HLA that could benefit from larger meta-genome-wide association studies.",

author = "Delnaz Roshandel and Athina Spiliopoulou and McGurnaghan, {Stuart J.} and Andrii Iakovliev and Debby Lipschutz and Caroline Hayward and Bull, {Shelley B.} and Klein, {Barbara E.K.} and Lee, {Kristine E.} and Kinney, {Gregory L.} and Marian Rewers and Tina Costacou and Miller, {Rachel G.} and McKeigue, {Paul M.} and Paterson, {Andrew D.} and Colhoun, {Helen M.}",

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doi = "10.2337/db24-0340",

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T1 - Genetics of C-Peptide and Age at Diagnosis in Type 1 Diabetes

AU - Roshandel, Delnaz

AU - Spiliopoulou, Athina

AU - McGurnaghan, Stuart J.

AU - Iakovliev, Andrii

AU - Lipschutz, Debby

AU - Hayward, Caroline

AU - Bull, Shelley B.

AU - Klein, Barbara E.K.

AU - Lee, Kristine E.

AU - Kinney, Gregory L.

AU - Rewers, Marian

AU - Costacou, Tina

AU - Miller, Rachel G.

AU - McKeigue, Paul M.

AU - Paterson, Andrew D.

AU - Colhoun, Helen M.

PY - 2025/2/1

Y1 - 2025/2/1

N2 - ARTICLE HIGHLIGHTS: Identified genetic loci for C-peptide and type 1 diabetes (T1D) age at diagnosis (AAD) explain only a small proportion of their variation. We aimed to identify additional genetic loci associated with C-peptide and AAD. Some HLA allele/haplotypes associated with T1D also contributed to variability of C-peptide and AAD, whereas outside the HLA region, T1D loci were mostly not associated with C-peptide or AAD. Genetic variation within CTSH can affect AAD. There is still residual heritability of C-peptide and AAD outside of HLA that could benefit from larger meta-genome-wide association studies.

AB - ARTICLE HIGHLIGHTS: Identified genetic loci for C-peptide and type 1 diabetes (T1D) age at diagnosis (AAD) explain only a small proportion of their variation. We aimed to identify additional genetic loci associated with C-peptide and AAD. Some HLA allele/haplotypes associated with T1D also contributed to variability of C-peptide and AAD, whereas outside the HLA region, T1D loci were mostly not associated with C-peptide or AAD. Genetic variation within CTSH can affect AAD. There is still residual heritability of C-peptide and AAD outside of HLA that could benefit from larger meta-genome-wide association studies.

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U2 - 10.2337/db24-0340

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SN - 0012-1797

VL - 74

SP - 223

EP - 233

JO - Diabetes

JF - Diabetes

IS - 2

ER -

Genetics of C-Peptide and Age at Diagnosis in Type 1 Diabetes

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