Genetics of dyslexia

Qianyun Ling, Elinor Bridges, Michelle Luciano

Research output: Chapter in Book/Report/Conference proceedingOther chapter contribution

Abstract / Description of output

Dyslexia is a common disorder of reading and spelling which can negatively affect the development and attainment of school-aged children, with deficits emerging in early childhood and persisting into adulthood. The unstable definition of dyslexia poses challenges for identifying dyslexia and for research. Family studies show a familial aggregation of dyslexia, with twin studies estimating the heritability (the proportion of total variance due to genes) at around 40–60%. Genetic linkage and association methods focussing on high-risk families led the way in genetic research aiming to localise chromosomal regions and candidate genes associated with dyslexia, although with mixed success. Genome-wide association studies have recently made important genetic discoveries in dyslexia, revealing its polygenic nature and identifying genes and biological pathways, many of which were successfully replicated in independent samples. The potential to construct polygenic scores that predict the development of dyslexia may offer a new route for earlier and more refined diagnosis in future.
Original languageEnglish
Title of host publicationeLS
PublisherWiley
Volume3
Edition3
ISBN (Electronic) 9780470015902
DOIs
Publication statusE-pub ahead of print - 16 Nov 2022

Publication series

NameeLS
PublisherWiley

Keywords / Materials (for Non-textual outputs)

  • GWAS
  • dyslexia
  • genetic correlations
  • twin studies
  • heritability
  • polygenic scores
  • reading
  • spelling

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