Genetics of Schizophrenia

Irene Escudero, Mandy Johnstone*

*Corresponding author for this work

Research output: Contribution to journalLiterature reviewpeer-review

Abstract / Description of output

The genetic basis of schizophrenia has been a hotly debated research topic for decades, yet recent studies, especially in the past year, have confirmed genetics as the major cause of this complex condition. Psychiatry has come of age: it is perhaps more difficult for the current generation of psychiatrists, to comprehend how the biological root of the condition could have been denied for so long. Here we review how highly collaborative global efforts to pool samples, utilise the very latest advances in genotyping and high throughput sequencing technologies, and application of robust statistical analysis have reaped phenomenal rewards. The major findings are that schizophrenia is a highly polygenic disorder with a complex array of risk loci, many include genes implicated also in intellectual disability, autism spectrum disorders, bipolar disorder and major depressive disorder. These candidate genes converge on key neuronal signalling pathways identifying novel targets for potential future therapeutic intervention.

Original languageEnglish
Article number502
Number of pages6
JournalCurrent psychiatry reports
Volume16
Issue number11
DOIs
Publication statusPublished - Nov 2014

Keywords / Materials (for Non-textual outputs)

  • Schizophrenia
  • Genetics
  • Copy number variants
  • Single nucleotide polymorphisms
  • Common variants
  • Rare variants
  • Neurodevelopmental disorders
  • GENOME-WIDE ASSOCIATION
  • BRAIN-DEVELOPMENT
  • BIPOLAR DISORDER
  • ANIMAL-MODELS
  • RISK LOCI
  • MUTATIONS
  • DISC1
  • ENDOPHENOTYPE
  • TRANSLOCATION
  • ARCHITECTURE

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