Genetics, Recombination and Clinical Features of Human Rhinovirus Species C (HRV-C) Infections; Interactions of HRV-C with Other Respiratory Viruses

A. Wisdom, A.E. Kutkowska, E.C. McWilliam Leitch, Eleanor R Gaunt, K. Templeton, H. Harvala, P. Simmonds

Research output: Contribution to journalArticlepeer-review

Abstract

To estimate the frequency, molecular epidemiological and clinical associations of infection with the newly described species C variants of human rhinoviruses (HRV), 3243 diagnostic respiratory samples referred for diagnostic testing in Edinburgh were screened using a VP4-encoding region-based selective polymerase chain reaction (PCR) for HRV-C along with parallel PCR testing for 13 other respiratory viruses. HRV-C was the third most frequently detected behind respiratory syncytial virus (RSV) and adenovirus, with 141 infection episodes detected among 1885 subjects over 13 months (7.5%). Infections predominantly targeted the very young (median age 6-12 months; 80% of infections in those
Original languageEnglish
Article numbere9518
Number of pages9
JournalPLoS ONE
Volume4
Issue number12
DOIs
Publication statusPublished - Dec 2009

Fingerprint

Dive into the research topics of 'Genetics, Recombination and Clinical Features of Human Rhinovirus Species C (HRV-C) Infections; Interactions of HRV-C with Other Respiratory Viruses'. Together they form a unique fingerprint.

Cite this