Genome architecture: domain organization of interphase chromosomes

Wendy A. Bickmore, Bas van Steensel

Research output: Contribution to journalLiterature reviewpeer-review

Abstract

The architecture of interphase chromosomes is important for the regulation of gene expression and genome maintenance. Chromosomes are linearly segmented into hundreds of domains with different protein compositions. Furthermore, the spatial organization of chromosomes is nonrandom and is characterized by many local and long-range contacts among genes and other sequence elements. A variety of genome-wide mapping techniques have made it possible to chart these properties at high resolution. Combined with microscopy and computational modeling, the results begin to yield a more coherent picture that integrates linear and three-dimensional (3D) views of chromosome organization in relation to gene regulation and other nuclear functions.
Original languageEnglish
Pages (from-to)1270-1284
Number of pages15
JournalCell
Volume152
Issue number6
DOIs
Publication statusPublished - 14 Mar 2013

Keywords

  • EMBRYONIC STEM-CELLS
  • SPATIAL-ORGANIZATION
  • CHROMATIN DOMAINS
  • GENE-EXPRESSION
  • RANGE DNA INTERACTIONS
  • DROSOPHILA GENOME
  • X-INACTIVATION
  • TRANSCRIPTOME MAP
  • 3-DIMENSIONAL ARCHITECTURE
  • NUCLEAR LAMINA INTERACTIONS

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