Projects per year
Abstract
The architecture of interphase chromosomes is important for the regulation of gene expression and genome maintenance. Chromosomes are linearly segmented into hundreds of domains with different protein compositions. Furthermore, the spatial organization of chromosomes is nonrandom and is characterized by many local and long-range contacts among genes and other sequence elements. A variety of genome-wide mapping techniques have made it possible to chart these properties at high resolution. Combined with microscopy and computational modeling, the results begin to yield a more coherent picture that integrates linear and three-dimensional (3D) views of chromosome organization in relation to gene regulation and other nuclear functions.
Original language | English |
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Pages (from-to) | 1270-1284 |
Number of pages | 15 |
Journal | Cell |
Volume | 152 |
Issue number | 6 |
DOIs | |
Publication status | Published - 14 Mar 2013 |
Keywords / Materials (for Non-textual outputs)
- EMBRYONIC STEM-CELLS
- SPATIAL-ORGANIZATION
- CHROMATIN DOMAINS
- GENE-EXPRESSION
- RANGE DNA INTERACTIONS
- DROSOPHILA GENOME
- X-INACTIVATION
- TRANSCRIPTOME MAP
- 3-DIMENSIONAL ARCHITECTURE
- NUCLEAR LAMINA INTERACTIONS
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Dive into the research topics of 'Genome architecture: domain organization of interphase chromosomes'. Together they form a unique fingerprint.Projects
- 2 Finished
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The role of spatial nuclear organisation in genome function
Bickmore, W. (Principal Investigator)
1/04/12 → 31/03/18
Project: Research
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FunctionalEdge: Determining the roles of the nuclear peri
Bickmore, W. (Principal Investigator)
1/10/11 → 28/02/16
Project: Research