Genome architecture: domain organization of interphase chromosomes

Wendy A. Bickmore; Bas van Steensel

doi:10.1016/j.cell.2013.02.001

Genome architecture: domain organization of interphase chromosomes

Wendy A. Bickmore^*, Bas van Steensel

^*Corresponding author for this work

Research output: Contribution to journal › Literature review › peer-review

Abstract

The architecture of interphase chromosomes is important for the regulation of gene expression and genome maintenance. Chromosomes are linearly segmented into hundreds of domains with different protein compositions. Furthermore, the spatial organization of chromosomes is nonrandom and is characterized by many local and long-range contacts among genes and other sequence elements. A variety of genome-wide mapping techniques have made it possible to chart these properties at high resolution. Combined with microscopy and computational modeling, the results begin to yield a more coherent picture that integrates linear and three-dimensional (3D) views of chromosome organization in relation to gene regulation and other nuclear functions.

Original language	English
Pages (from-to)	1270-1284
Number of pages	15
Journal	Cell
Volume	152
Issue number	6
DOIs	https://doi.org/10.1016/j.cell.2013.02.001
Publication status	Published - 14 Mar 2013

Keywords / Materials (for Non-textual outputs)

EMBRYONIC STEM-CELLS
SPATIAL-ORGANIZATION
CHROMATIN DOMAINS
GENE-EXPRESSION
RANGE DNA INTERACTIONS
DROSOPHILA GENOME
X-INACTIVATION
TRANSCRIPTOME MAP
3-DIMENSIONAL ARCHITECTURE
NUCLEAR LAMINA INTERACTIONS

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10.1016/j.cell.2013.02.001

The role of spatial nuclear organisation in genome function
Bickmore, W. (Principal Investigator)
1/04/12 → 31/03/18
Project: Research
FunctionalEdge: Determining the roles of the nuclear peri
Bickmore, W. (Principal Investigator)
EU government bodies
1/10/11 → 28/02/16
Project: Research

Cite this

@article{2f2a860462204396b7f3f25fb5c4ff87,

title = "Genome architecture: domain organization of interphase chromosomes",

abstract = "The architecture of interphase chromosomes is important for the regulation of gene expression and genome maintenance. Chromosomes are linearly segmented into hundreds of domains with different protein compositions. Furthermore, the spatial organization of chromosomes is nonrandom and is characterized by many local and long-range contacts among genes and other sequence elements. A variety of genome-wide mapping techniques have made it possible to chart these properties at high resolution. Combined with microscopy and computational modeling, the results begin to yield a more coherent picture that integrates linear and three-dimensional (3D) views of chromosome organization in relation to gene regulation and other nuclear functions.",

keywords = "EMBRYONIC STEM-CELLS, SPATIAL-ORGANIZATION, CHROMATIN DOMAINS, GENE-EXPRESSION, RANGE DNA INTERACTIONS, DROSOPHILA GENOME, X-INACTIVATION, TRANSCRIPTOME MAP, 3-DIMENSIONAL ARCHITECTURE, NUCLEAR LAMINA INTERACTIONS",

author = "Bickmore, {Wendy A.} and {van Steensel}, Bas",

year = "2013",

month = mar,

day = "14",

doi = "10.1016/j.cell.2013.02.001",

language = "English",

volume = "152",

pages = "1270--1284",

journal = "Cell",

issn = "0092-8674",

publisher = "Elsevier",

number = "6",

}

TY - JOUR

T1 - Genome architecture

T2 - domain organization of interphase chromosomes

AU - Bickmore, Wendy A.

AU - van Steensel, Bas

PY - 2013/3/14

Y1 - 2013/3/14

N2 - The architecture of interphase chromosomes is important for the regulation of gene expression and genome maintenance. Chromosomes are linearly segmented into hundreds of domains with different protein compositions. Furthermore, the spatial organization of chromosomes is nonrandom and is characterized by many local and long-range contacts among genes and other sequence elements. A variety of genome-wide mapping techniques have made it possible to chart these properties at high resolution. Combined with microscopy and computational modeling, the results begin to yield a more coherent picture that integrates linear and three-dimensional (3D) views of chromosome organization in relation to gene regulation and other nuclear functions.

AB - The architecture of interphase chromosomes is important for the regulation of gene expression and genome maintenance. Chromosomes are linearly segmented into hundreds of domains with different protein compositions. Furthermore, the spatial organization of chromosomes is nonrandom and is characterized by many local and long-range contacts among genes and other sequence elements. A variety of genome-wide mapping techniques have made it possible to chart these properties at high resolution. Combined with microscopy and computational modeling, the results begin to yield a more coherent picture that integrates linear and three-dimensional (3D) views of chromosome organization in relation to gene regulation and other nuclear functions.

KW - EMBRYONIC STEM-CELLS

KW - SPATIAL-ORGANIZATION

KW - CHROMATIN DOMAINS

KW - GENE-EXPRESSION

KW - RANGE DNA INTERACTIONS

KW - DROSOPHILA GENOME

KW - X-INACTIVATION

KW - TRANSCRIPTOME MAP

KW - 3-DIMENSIONAL ARCHITECTURE

KW - NUCLEAR LAMINA INTERACTIONS

U2 - 10.1016/j.cell.2013.02.001

DO - 10.1016/j.cell.2013.02.001

M3 - Literature review

C2 - 23498936

SN - 0092-8674

VL - 152

SP - 1270

EP - 1284

JO - Cell

JF - Cell

IS - 6

ER -

Genome architecture: domain organization of interphase chromosomes

Abstract

Keywords / Materials (for Non-textual outputs)

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Projects

The role of spatial nuclear organisation in genome function

FunctionalEdge: Determining the roles of the nuclear peri

Cite this