Genome of the host-cell transforming parasite Theileria annulata compared with T. parva

Arnab Pain; Hubert Renauld; Matthew Berriman; Lee Murphy; Corin A Yeats; William Weir; Arnaud Kerhornou; Martin Aslett; Richard Bishop; Christiane Bouchier; Madeleine Cochet; Richard M R Coulson; Ann Cronin; Etienne P de Villiers; Audrey Fraser; Nigel Fosker; Malcolm Gardner; Arlette Goble; Sam Griffiths-Jones; David E Harris; Frank Katzer; Natasha Larke; Angela Lord; Pascal Maser; Sue McKellar; Paul Mooney; Fraser Morton; Vishvanath Nene; Susan O'Neil; Claire Price; Michael A Quail; Ester Rabbinowitsch; Neil D Rawlings; Simon Rutter; David Saunders; Kathy Seeger; Trushar Shah; Robert Squares; Steven Squares; Adrian Tivey; Alan R Walker; John Woodward; Dirk A E Dobbelaere; Gordon Langsley; Marie-Adele Rajandream; Declan McKeever; Brian Shiels; Andrew Tait; Bart Barrell; Neil Hall

doi:10.1126/science.1110418

Genome of the host-cell transforming parasite Theileria annulata compared with T. parva

Arnab Pain, Hubert Renauld, Matthew Berriman, Lee Murphy, Corin A Yeats, William Weir, Arnaud Kerhornou, Martin Aslett, Richard Bishop, Christiane Bouchier, Madeleine Cochet, Richard M R Coulson, Ann Cronin, Etienne P de Villiers, Audrey Fraser, Nigel Fosker, Malcolm Gardner, Arlette Goble, Sam Griffiths-Jones, David E HarrisFrank Katzer, Natasha Larke, Angela Lord, Pascal Maser, Sue McKellar, Paul Mooney, Fraser Morton, Vishvanath Nene, Susan O'Neil, Claire Price, Michael A Quail, Ester Rabbinowitsch, Neil D Rawlings, Simon Rutter, David Saunders, Kathy Seeger, Trushar Shah, Robert Squares, Steven Squares, Adrian Tivey, Alan R Walker, John Woodward, Dirk A E Dobbelaere, Gordon Langsley, Marie-Adele Rajandream, Declan McKeever, Brian Shiels, Andrew Tait, Bart Barrell, Neil Hall

Research output: Contribution to journal › Article › peer-review

Abstract

Theileria annulata and T. parva are closely related protozoan parasites that cause lymphoproliferative diseases of cattle. We sequenced the genome of T. annulata and compared it with that of T. parva to understand the mechanisms underlying transformation and tropism. Despite high conservation of gene sequences and synteny, the analysis reveals unequally expanded gene families and species-specific genes. We also identify divergent families of putative secreted polypeptides that may reduce immune recognition, candidate regulators of host-cell transformation, and a Theileria-specific protein domain [frequently associated in Theileria (FAINT)] present in a large number of secreted proteins.

Original language	English
Pages (from-to)	131-3
Number of pages	3
Journal	Science
Volume	309
Issue number	5731
DOIs	https://doi.org/10.1126/science.1110418
Publication status	Published - 1 Jul 2005

Keywords / Materials (for Non-textual outputs)

Amino Acid Motifs
Animals
Cattle
Cell Proliferation
Chromosome Mapping
Chromosomes
Conserved Sequence
Genes, Protozoan
Genome, Protozoan
Life Cycle Stages
Lipid Metabolism
Lymphocytes
Molecular Sequence Data
Multigene Family
Phylogeny
Protein Sorting Signals
Protein Structure, Tertiary
Proteome
Protozoan Proteins
Sequence Analysis, DNA
Species Specificity
Synteny
Telomere
Theileria annulata
Theileria parva

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10.1126/science.1110418

Cite this

Pain, A., Renauld, H., Berriman, M., Murphy, L., Yeats, C. A., Weir, W., Kerhornou, A., Aslett, M., Bishop, R., Bouchier, C., Cochet, M., Coulson, R. M. R., Cronin, A., de Villiers, E. P., Fraser, A., Fosker, N., Gardner, M., Goble, A., Griffiths-Jones, S., ... Hall, N. (2005). Genome of the host-cell transforming parasite Theileria annulata compared with T. parva. Science, 309(5731), 131-3. https://doi.org/10.1126/science.1110418

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title = "Genome of the host-cell transforming parasite Theileria annulata compared with T. parva",

abstract = "Theileria annulata and T. parva are closely related protozoan parasites that cause lymphoproliferative diseases of cattle. We sequenced the genome of T. annulata and compared it with that of T. parva to understand the mechanisms underlying transformation and tropism. Despite high conservation of gene sequences and synteny, the analysis reveals unequally expanded gene families and species-specific genes. We also identify divergent families of putative secreted polypeptides that may reduce immune recognition, candidate regulators of host-cell transformation, and a Theileria-specific protein domain [frequently associated in Theileria (FAINT)] present in a large number of secreted proteins.",

keywords = "Amino Acid Motifs, Animals, Cattle, Cell Proliferation, Chromosome Mapping, Chromosomes, Conserved Sequence, Genes, Protozoan, Genome, Protozoan, Life Cycle Stages, Lipid Metabolism, Lymphocytes, Molecular Sequence Data, Multigene Family, Phylogeny, Protein Sorting Signals, Protein Structure, Tertiary, Proteome, Protozoan Proteins, Sequence Analysis, DNA, Species Specificity, Synteny, Telomere, Theileria annulata, Theileria parva",

author = "Arnab Pain and Hubert Renauld and Matthew Berriman and Lee Murphy and Yeats, {Corin A} and William Weir and Arnaud Kerhornou and Martin Aslett and Richard Bishop and Christiane Bouchier and Madeleine Cochet and Coulson, {Richard M R} and Ann Cronin and {de Villiers}, {Etienne P} and Audrey Fraser and Nigel Fosker and Malcolm Gardner and Arlette Goble and Sam Griffiths-Jones and Harris, {David E} and Frank Katzer and Natasha Larke and Angela Lord and Pascal Maser and Sue McKellar and Paul Mooney and Fraser Morton and Vishvanath Nene and Susan O'Neil and Claire Price and Quail, {Michael A} and Ester Rabbinowitsch and Rawlings, {Neil D} and Simon Rutter and David Saunders and Kathy Seeger and Trushar Shah and Robert Squares and Steven Squares and Adrian Tivey and Walker, {Alan R} and John Woodward and Dobbelaere, {Dirk A E} and Gordon Langsley and Marie-Adele Rajandream and Declan McKeever and Brian Shiels and Andrew Tait and Bart Barrell and Neil Hall",

year = "2005",

month = jul,

day = "1",

doi = "10.1126/science.1110418",

language = "English",

volume = "309",

pages = "131--3",

journal = "Science",

issn = "0036-8075",

publisher = "AMER ASSOC ADVANCEMENT SCIENCE",

number = "5731",

}

Pain, A, Renauld, H, Berriman, M, Murphy, L, Yeats, CA, Weir, W, Kerhornou, A, Aslett, M, Bishop, R, Bouchier, C, Cochet, M, Coulson, RMR, Cronin, A, de Villiers, EP, Fraser, A, Fosker, N, Gardner, M, Goble, A, Griffiths-Jones, S, Harris, DE, Katzer, F, Larke, N, Lord, A, Maser, P, McKellar, S, Mooney, P, Morton, F, Nene, V, O'Neil, S, Price, C, Quail, MA, Rabbinowitsch, E, Rawlings, ND, Rutter, S, Saunders, D, Seeger, K, Shah, T, Squares, R, Squares, S, Tivey, A, Walker, AR, Woodward, J, Dobbelaere, DAE, Langsley, G, Rajandream, M-A, McKeever, D, Shiels, B, Tait, A, Barrell, B & Hall, N 2005, 'Genome of the host-cell transforming parasite Theileria annulata compared with T. parva', Science, vol. 309, no. 5731, pp. 131-3. https://doi.org/10.1126/science.1110418

TY - JOUR

T1 - Genome of the host-cell transforming parasite Theileria annulata compared with T. parva

AU - Pain, Arnab

AU - Renauld, Hubert

AU - Berriman, Matthew

AU - Murphy, Lee

AU - Yeats, Corin A

AU - Weir, William

AU - Kerhornou, Arnaud

AU - Aslett, Martin

AU - Bishop, Richard

AU - Bouchier, Christiane

AU - Cochet, Madeleine

AU - Coulson, Richard M R

AU - Cronin, Ann

AU - de Villiers, Etienne P

AU - Fraser, Audrey

AU - Fosker, Nigel

AU - Gardner, Malcolm

AU - Goble, Arlette

AU - Griffiths-Jones, Sam

AU - Harris, David E

AU - Katzer, Frank

AU - Larke, Natasha

AU - Lord, Angela

AU - Maser, Pascal

AU - McKellar, Sue

AU - Mooney, Paul

AU - Morton, Fraser

AU - Nene, Vishvanath

AU - O'Neil, Susan

AU - Price, Claire

AU - Quail, Michael A

AU - Rabbinowitsch, Ester

AU - Rawlings, Neil D

AU - Rutter, Simon

AU - Saunders, David

AU - Seeger, Kathy

AU - Shah, Trushar

AU - Squares, Robert

AU - Squares, Steven

AU - Tivey, Adrian

AU - Walker, Alan R

AU - Woodward, John

AU - Dobbelaere, Dirk A E

AU - Langsley, Gordon

AU - Rajandream, Marie-Adele

AU - McKeever, Declan

AU - Shiels, Brian

AU - Tait, Andrew

AU - Barrell, Bart

AU - Hall, Neil

PY - 2005/7/1

Y1 - 2005/7/1

N2 - Theileria annulata and T. parva are closely related protozoan parasites that cause lymphoproliferative diseases of cattle. We sequenced the genome of T. annulata and compared it with that of T. parva to understand the mechanisms underlying transformation and tropism. Despite high conservation of gene sequences and synteny, the analysis reveals unequally expanded gene families and species-specific genes. We also identify divergent families of putative secreted polypeptides that may reduce immune recognition, candidate regulators of host-cell transformation, and a Theileria-specific protein domain [frequently associated in Theileria (FAINT)] present in a large number of secreted proteins.

AB - Theileria annulata and T. parva are closely related protozoan parasites that cause lymphoproliferative diseases of cattle. We sequenced the genome of T. annulata and compared it with that of T. parva to understand the mechanisms underlying transformation and tropism. Despite high conservation of gene sequences and synteny, the analysis reveals unequally expanded gene families and species-specific genes. We also identify divergent families of putative secreted polypeptides that may reduce immune recognition, candidate regulators of host-cell transformation, and a Theileria-specific protein domain [frequently associated in Theileria (FAINT)] present in a large number of secreted proteins.

KW - Amino Acid Motifs

KW - Animals

KW - Cattle

KW - Cell Proliferation

KW - Chromosome Mapping

KW - Chromosomes

KW - Conserved Sequence

KW - Genes, Protozoan

KW - Genome, Protozoan

KW - Life Cycle Stages

KW - Lipid Metabolism

KW - Lymphocytes

KW - Molecular Sequence Data

KW - Multigene Family

KW - Phylogeny

KW - Protein Sorting Signals

KW - Protein Structure, Tertiary

KW - Proteome

KW - Protozoan Proteins

KW - Sequence Analysis, DNA

KW - Species Specificity

KW - Synteny

KW - Telomere

KW - Theileria annulata

KW - Theileria parva

U2 - 10.1126/science.1110418

DO - 10.1126/science.1110418

M3 - Article

C2 - 15994557

SN - 0036-8075

VL - 309

SP - 131

EP - 133

JO - Science

JF - Science

IS - 5731

ER -

Genome of the host-cell transforming parasite Theileria annulata compared with T. parva

Abstract

Keywords / Materials (for Non-textual outputs)

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